Proteomics of the mediodorsal thalamic nucleus of rats with stress-induced gastric ulcer

Table 1 Brain nuclei and neurotransmitters/hormones involved in restraint water-immersion stress

Nucleus	Neurotransmitter or hormone
Dorsal motor nucleus of the vagus[10]	Acetylcholine[19]
Nucleus ambiguous[10]	Norepinephrine[13]
Nucleus of solitary tract[10]	Oxytocin[14]
Paraventricular nucleus[10]	Arginine vasopressin[14,15]
Supraoptic nucleus[11]	Hydrogen peroxide[20]

Table 2 Top ten most enriched pathways indentified by an ingenuity pathway analysis of the dysregulated proteins according to –log (P-value)

Pathway name	-log (P-value)	Enriched dysregulated proteins
NRF2-mediated oxidative stress response	3.69	GSTM2, DNAJB1, GSK3B, CBR1, DNAJC11
EIF2 signalling	3.42	PTBP1, RPL18A, RPL3, EIF2S3, GSK3B
Fatty acid β-oxidation I	2.44	ACSL5, HSD17B4
Cysteine biosynthesis/homocysteine degradation	2.25	CBS/CBSL
Caveolar-mediated endocytosis signalling	1.77	ARCN1, ITGA6
Melatonin signalling	1.77	CAMK2D, ARAF
Integrin signalling	1.63	WASL, ITGA6, GSK3B
Protein kinase A signalling	1.62	CAMK2D, PTPN9, GSK3B, CDC16
Prostanoid biosynthesis	1.6	PTGDS
Reelin signalling in neurons	1.56	ITGA6, GSK3B

ACSL5: Long-chain acyl-CoA synthetase 5; ARAF: Serine/threonine-protein kinase; ARCN1: Archain 1; CAMK2D: Calcium/calmodulin-dependent kinase II; CBR1: Cannabinoid receptor 1; CBS/CBSL: Cystathionine beta-synthase; CDC16: Cell division cycle16; DNAJB1: DnaJ homolog subfamily B member I; DNAJC11: Rattus norvegicus DnaJ (Hsp40) homolog, subfamily C, member 11; EIF2S3: Eukaryotic translation initiation factor (eIF) 2 subunit 3; HSD17B4: 17β-Hydroxysteroid dehydrogenaseIV; GSK3B: Glycogen synthase kinase 3B; GSTM2: Glutathione-s-transferase μ 2; CBR1: Canine carbonyl reductase 1; ITGA6: Integrin α6; PTGDS: Prostaglandin D2 synthase; PTBP1: Polypyrimidine tract-binding protein 1; PTPN9: Protein tyrosine phosphatase non-receptor type 9; RPL3: Ribosomal protein L3; RPL18A: Ribosomal protein L18A; WASL: Wiskott aldrich syndrome like protein.