Seven-senescence-associated gene signature predicts overall survival for Asian patients with hepatocellular carcinoma

doi:10.3748/wjg.v25.i14.1715

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 14, 2019; 25(14): 1715-1728
Published online Apr 14, 2019. doi: 10.3748/wjg.v25.i14.1715

Table 1 Univariate/multivariate Cox regression analysis of clinicopathologic factors associated with overall survival in GSE14520 and The Cancer Genome Atlas cohorts

Variable	Discovery cohort				Validation cohort-Asian only
	Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis
	HR (95%CI)	P-value	HR (95%CI)	P-value	HR (95%CI)	P-value	HR (95%CI)	P-value
Gender (male/female)	1.36 (0.55-3.40)	0.507	-	-	0.89 (0.43-1.86)	0.755	-	-
Age (> 60/≤ 60 yr)	1.06 (0.57-2.00)	0.851	-	-	1.21 (0.66-2.24)	0.541	-	-
Cirrhosis (yes/no)	3.09 (0.76-12.65)	0.117	-	-	2.44 (1.56-3.85)	< 0.001^a	1.67 (1.04-2.70)	0.034^a
AFP (> 300/≤ 300 ng/mL)	2.30 (1.37-3.86)	0.002^a	2.26 (1.38-3.69)	0.001^a	3.70 (2.13-6.25)	< 0.001^a	2.13 (1.30-3.57)	0.003^a
Risk score (high/low)	1.93 (1.15-3.23)	0.012^a	1.99 (1.19-3.34)	0.009^a	5.91 (2.74-12.76)	< 0.001^a	4.22 (1.89-9.41)	< 0.001^a

^aStatistically significant. HR: Hazard ratio; CI: Confidence interval; AFP: Alpha-fetoprotein.

Table 2 Stratified analysis of overall survival in GSE14520 and The Cancer Genome Atlas cohorts

Variable	Discovery cohort			Validation cohort-Asian only
Variable	High-risk/low-risk	HR (95%CI)	P-value	High-risk/low-risk	HR (95%CI)	P-value
Overall	76/75	1.92 (1.16-3.19)	0.011^a	79/78	5.81 (3.20-10.54)	< 0.001^a
Gender
Male	69/67	2.15 (1.27-3.64)	0.004^a	62/61	5.18 (2.66-10.10)	< 0.001^a
Female	7/8	0.60 (0.10-3.47)	0.569	17/17	9.63 (2.59-35.77)	0.009^a
Age (yr)
≤ 60	64/60	1.70 (0.97-2.98)	0.064	53/52	5.22 (2.49-10.97)	< 0.001^a
> 60	12/15	3.19 (1.00-10.20)	0.045^a	26/26	6.47 (2.38-17.59)	< 0.001^a
Cirrhosis
Yes	70/69	1.93 (1.15-3.22)	0.012^a	17/24	3.50 (0.66-18.47)	0.122
No	6/6	1.73 (0.10-30.65)	0.695	11/28	0.98 (0.19-5.00)	0.979
AFP (ng/mL)
≤ 300	40/39	1.73 (0.77-3.87)	0.179	34/55	2.94 (1.01-8.57)	0.036^a
> 300	34/34	2.11 (1.09-4.08)	0.025^a	16/16	2.65 (0.60-11.66)	0.226

^aStatistically significant. HR: Hazard ratio; CI: Confidence interval; AFP: Alpha-fetoprotein.

Citation: Xiang XH, Yang L, Zhang X, Ma XH, Miao RC, Gu JX, Fu YN, Yao Q, Zhang JY, Liu C, Lin T, Qu K. Seven-senescence-associated gene signature predicts overall survival for Asian patients with hepatocellular carcinoma. World J Gastroenterol 2019; 25(14): 1715-1728
URL: https://www.wjgnet.com/1007-9327/full/v25/i14/1715.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i14.1715