Predicting the presence of adenomatous polyps during colonoscopy with National Cancer Institute Colorectal Cancer Risk-Assessment Tool

Table 1 Demographic information stratified by adenomatous polyp prevalence n (%)

	Adenoma absent	Adenoma present	Total	P value
Total	436 (58.2)	313 (41.79)	749 (100)
Age				0.043
Mean ± SD	58.656 ± 7.321	59.764 10 ± 7.417	59.119 ± 7.376
Gender				0.798
Male	180 (41.3)	133 (42.5)	313 (41.8)
Female	256 (58.7)	180 (57.5)	436 (58.2)
Race				0.243
White	29 (6.7)	33 (10.6)	62 (8.3)
African american	104 (23.9)	74 (23.7)	178 (23.8)
Asian	5 (1.1)	2 (0.6)	7 (0.9)
Hispanic	298 (68.3)	203 (65.1)	501 (67.0)
Indication of colonoscopy				0.279
Surveillance	77 (17.7)	66 (21.1)	143 (19.1)
Screening	359 (82.3)	247 (78.9)	606 (80.9)

Table 2 Adenoma prevalence by risk-score quintile for all patients

NCI lifetime risk score quintile	Score range	Number of individuals with adenomas (%)	OR of an adenoma (95%CI): row quintile vs column quintile
			Q1	Q2	Q3	Q4
Q1 lowest	(1.1, 1.9)	42 (27.63)	-	-	-	-
Q2	(1.9, 2.8)	55 (33.54)	1.32 (0.82, 2.14)	-	-	-
Q3	(2.8, 4.0)	69 (46.31)	2.26 (1.40, 3.65)	1.71 (1.08, 2.70)	-	-
Q4	(4.0, 5.4)	71 (52.21)	2.86 (1.75, 4.67)	2.16 (1.36, 3.45)	1.27 (0.79, 2.02)	-
Q5 highest	(5.4, 12.3)	76 (51.35)	2.76 (1.71, 4.47)	2.09 (1.32, 3.30)	1.22 (0.78, 1.93)	0.97 (0.61, 1.54)

Asymptotic Linear-by-Linear Association Test: P < 0.001. OR: Odds ratio; CI: Confidence interval; NCI: National Cancer Institute.

Table 3 Disease prevalence stratified by risk score optimal cutoff value n (%)

	< 3.6 (n = 373)	≥ 3.6 (n = 376)	Total (n = 749)	P value
Adenoma present	115 (30.8)	198 (52.7)	313 (41.8)	< 0.001
Adenoma (number)				< 0.001
< 3	355 (95.2)	321 (85.4)	676 (90.3)
≥ 3	18 (4.8)	55 (14.6)	73 (9.7)
Serrated adenoma present	1 (0.3)	2 (0.5)	3 (0.4)	1.000
Hyperplastic polyp > 10 mm present	7 (1.9)	10 (2.7)	17 (2.3)	0.632

Table 4 Adenoma prevalence by risk-score quintile for all screening patients

NCI lifetime risk score quintile	Score range	Number of individuals with adenomas (%)	OR of an adenoma (95%CI): row quintile vs column quintile
			Q1	Q2	Q3	Q4
Q1 lowest	(1.1, 1.9)	35 (28.69)	-	-	-	-
Q2	(1.9, 2.8)	45 (33.58)	1.26 (0.74, 2.14)	-	-	-
Q3	(2.8, 4.0)	52 (43.70)	1.93 (1.13, 3.29)	1.53 (0.92, 2.56)	-	-
Q4	(4.0, 5.5)	62 (51.67)	2.66 (1.56, 4.52)	2.11 (1.27, 3.51)	1.38 (0.83, 2.29)	-
Q5 highest	(5.5, 12.3)	53 (47.75)	2.27 (1.32, 3.90)	1.81 (1.08, 3.03)	1.18 (0.70, 1.98)	0.85 (0.51, 1.43)

Asymptotic Linear-by-Linear Association Test: P < 0.001. OR: Odds ratio; CI: Confidence interval; NCI: National Cancer Institute.