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©The Author(s) 2018.
World J Gastroenterol. Jan 21, 2018; 24(3): 387-396
Published online Jan 21, 2018. doi: 10.3748/wjg.v24.i3.387
Published online Jan 21, 2018. doi: 10.3748/wjg.v24.i3.387
Table 1 Demographic and clinical features, and biochemical parameters1 of biliary atresia patients and non-biliary atresia controls n (%)
Variable | BA, n = 124 | Non-BA, n = 140 | |
Other liver diseases2, n = 92 | Healthy, n = 48 | ||
Age, mo | 2.9 (1.9-3.0) | 2.8 (2.0-3.2) | 3.4 (2.0-4.0) |
Sex, male/female | 60/64 | 50/42 | 25/23 |
METAVIR score | |||
F0 | 4 (3.2) | NA | NA |
F1 | 37 (29.8) | NA | NA |
F2 | 24 (19.4) | NA | NA |
F3 | 50 (40.3) | NA | NA |
F4 | 9 (7.3) | NA | NA |
ALT, U/L | 162.4 (104.3-204.6)a | 132.0 (70.5-247.5) | 28.1 (22.4-40.8) |
AST, U/L | 190.5 (151.4-257.4)a | 195.9 (117.0-292.5) | 38.0 (26.0-52.3) |
γ-GT, U/L | 716.0 (411.0-1142.5)a | 598.4 (189.5-1043.2) | 32.7 (23.4-46.3) |
ALP, U/L | 406.8 (316.5-522.2)a | 517.0 (409.7-660.3) | 275.8 (189.0-345.6) |
TBIL, μmol/L | 157.0 (126.5-184.0)a | 145.7 (107.1-196.5) | 6.5 (2.8-14.8) |
DBIL, μmol/L | 130.5 (103.5-152.7)a | 110.1 (88.4-137.8) | 3.1 (1.0-4.9) |
Table 2 Prevalence profile of autoimmune liver disease in biliary atresia patients and non-biliary atresia controls n (%)
Variable | BA, n = 81 | Non-BA, n = 88 | ||
Other liver diseases1, n = 44 | Healthy, n = 40 | Total | ||
PBC-related antibodies | 15 (18.5)c | 4 (9.1) | 1 (2.5) | 5 (5.7) |
AMA-M2 | 1 (1.2) | 0 (0) | 0 (0) | 0 (0) |
Anti- BPO | 12 (14.8)ac | 2 (4.5) | 0 (0) | 2 (2.2) |
Anti-Sp100 | 1 (1.2) | 0 (0) | 0 (0) | 0 (0) |
Anti-gp210 | 2 (2.5) | 1 (2.3) | 1 (2.5) | 2 (2.2) |
Anti-PML | 3 (3.7) | 1 (2.3) | 0 (0) | 1 (1.1) |
AMA-M2 + anti-BPO | 1 (1.2) | 0 (0) | 0 (0) | 0 (0) |
AMA-M2 + anti-BPO + anti-Sp100 + anti-PML | 1 (1.2) | 0 (0) | 0 (0) | 0 (0) |
AIH-related antibodies | 6 (7.4) | 3 (6.8) | 3 (7.5) | 6 (6.8) |
Anti-LKM-1 | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
Anti-LC-1 | 5 (6.2) | 3 (6.8) | 3 (7.5) | 6 (6.8) |
Anti-SLA/LP | 1 (1.2) | 0 (0) | 0 (0) | 0 (0) |
Anti-Ro-52 | 5 (6.2) | 2 (4.5) | 2 (5) | 4 (4.5) |
Table 3 Prevalence of anti-nuclear antibodies in biliary atresia patients and non-biliary atresia controls n (%)
Variable | BA, n = 124 | Other liver diseases1, n = 92 | Healthy, n = 48 |
ANA, by IIF | 14 (11.3)c | 3 (3.3) | 2 (4.2) |
Fluorescence patterns | |||
Homogeneous | 3 (2.4) | 0 (0) | 0 (0) |
Speckled | 3 (2.4) | 0 (0) | 1 (2.1) |
Nucleolar | 3 (2.4) | 0 (0) | 1 (2.1) |
Nuclear dots | 1 (0.8) | 0 (0) | 0 (0) |
Centrosome | 1 (0.8) | 0 (0) | 0 (0) |
Cytoplasm | 1 (0.8) | 0 (0) | 0 (0) |
Ring or rod Golgi | 1 (0.8) | 2 (2.2) | 0 (0) |
Centromere | 1 (0.8) | 0 (0) | 0 (0) |
Spindle apparatus | 0 (0) | 1 (1.1) | 0 (0) |
Specific ANA2, by line-blot | |||
SSA | 1 (0.8) | 0 (0) | 0 (0) |
Ro-52 | 5 (4.0) | 2 (2.2) | 2 (4.2) |
CENP B | 4 (3.2) | 1 (1.1) | 0 (0) |
dsDNA | 3 (2.4) | 0 (0) | 0 (0) |
Table 4 Prevalence of anti-neutrophil cytoplasmic antibodies in biliary atresia patients and non-biliary atresia controls n (%)
Variable | BA, n = 124 | Other liver diseases1, n = 92 | Healthy, n = 48 |
ANCA, by IIF | 36 (29.0)a | 23 (25.0) | 2 (4.2) |
c-ANCA | 10 (8.1) | 1 (1.1) | 0 (0) |
p-ANCA | 25 (20.2) | 21 (22.8) | 2 (4.2) |
a-ANCA | 1 (0.8) | 1 (1.1) | 0 (0) |
Specific ANCA, by ELISA | |||
Anti-MPO | 11 (8.9) | 6 (6.5) | 2 (4.2) |
Anti-PR3 | 19 (15.3) | 13 (14.2) | 0 (0) |
Anti-MPO and/or anti-PR3 | 23 (18.0)a | 13 (14.2) | 2 (4.2) |
ANCAs | 47 (37.9)a | 31 (33.7) | 3 (6.3) |
Table 5 Association of autoantibodies and prognosis of Kasai procedure with follow-up of 52 biliary atresia patients n (%)
Parameter | Anti-M2-3E | ANA | ANCA | |||
Positive, n = 17 | Negative, n = 35 | Positive, n = 8 | Negative, n = 44 | Positive, n = 29 | Negative, n = 23 | |
TB, μmol/L | 105.5 ± 80.3 | 109.4 ± 106.8 | 41.6 ± 49.5 | 127.9 ± 135.0 | 133.0 ± 120.7 | 85.3 ± 66.2 |
ALT, U/L | 184.1 ± 119.8 | 171.7 ± 121.4 | 127.9 ± 135.0 | 185.8 ± 115.7 | 171.46 ± 95.5 | 179.6 ± 140.3 |
Occurrence of cholangitis | 9 (52.9) | 20 (57.1) | 5 (62.5) | 24 (54.5) | 24 (82.8)a | 5 (21.7)a |
- Citation: Pang SY, Dai YM, Zhang RZ, Chen YH, Peng XF, Fu J, Chen ZR, Liu YF, Yang LY, Wen Z, Yu JK, Liu HY. Autoimmune liver disease-related autoantibodies in patients with biliary atresia. World J Gastroenterol 2018; 24(3): 387-396
- URL: https://www.wjgnet.com/1007-9327/full/v24/i3/387.htm
- DOI: https://dx.doi.org/10.3748/wjg.v24.i3.387