Rethinking de novo immune hepatitis, an old concept for liver allograft rejection: Relevance of glutathione S-transferase T1 mismatch

Table 1 Reported cases of de novo autoimmune hepatitis in pediatric and adult liver transplantation

Ref.	de novo AIH/total patients	Original disease (immune-mediated)	Initial calcineurine inhibitor	Pediatric/adult
Kerkar et al[2] (1998)	7/180	4 BA	4 CyA, 3 Tac	P
Gupta et al[3] (2001)	6/115	5 BA	6 CyA	P
Andries et al[4] (2001)	11/471	7 BA	10 Cya, 1 Tac	P
Hernández et al[5] (2001)	5/155	4 BA, 1 PSC	5 CyA	P
Petz et al[6] (2002)	18/155	16 BA	9 Cya, 9 Tac	P
Miyagawa-Hayashino et al[7] (2003)	1	BA	Tac	P
Gibelli et al[8] (2006)	2/206	1 BA	CyA	P
Evans et al[9] (2006)	4/158	4 PSC	4 CyA	P
Riva et al[10] (2006)	9/247	9 BA	5 CyA, 4 Tac	P
Oya et al[11] (2009)	1	-	Tac	P
Cho et al[12] (2011)	4/148	1 BA	-	P
Pongpaibul et al[13] (2012)	51/685	29 BA	22 CyA, 29 Tac	P
Ekong et al[14] (2017)	29/1833	17 BA	13 CyA,16 Tac	P
Jones et al[15] (1999)	2	2 PBC	2 CyA	A
Heneghan et al[16] (2001)	7/1000	1 PBC, 2 PSC	7 CyA	A
Salcedo et al[17] (2002)	12/350	1 BA 1 PSC	12 CyA	A
Aguilera et al[18] (2004)	6/110	None	5 CyA, 1 Tac	A
1Update 2017	8	1 PBC, 1 PSC	8 CyA	A
Miyagawa-Hayashino et al[19] (2004)	13/633	11 BA	13 Tac	A
Tsuji et al[20] (2005)	1	PBC	CyA	A
Rodriguez-Diaz et al[21] (2006)	1	PBC	CyA	A
Yoshizawa et al[22] (2008)	1	PBC	Tac	A
Fiel et al[23] (2008)	38/?	none (HCV)	11 CyA, 27 Tac	A
Zhang et al[24] (2010)	1	PBC	Tac	A
Montano-Loza et al[25] (2012)	17/576	5 PBC, 1 BA	5 CyA, 7 Tac	A

¹Presently we have 8 more patients diagnosed. BA: Biliary atresia; PBC: Primary biliary cirrhosis; PSC: Primary sclerosing cholangitis; CyA: Cyclosporine A; Tac: Tacrolimus; A: Adult; P: Pediatric.