Copyright
©The Author(s) 2018.
World J Gastroenterol. Aug 7, 2018; 24(29): 3222-3238
Published online Aug 7, 2018. doi: 10.3748/wjg.v24.i29.3222
Published online Aug 7, 2018. doi: 10.3748/wjg.v24.i29.3222
ABC transporter | Tissue expression | Cancer overexpression | Correlation with PDAC survival (5-yr survival) |
ABCA | |||
ABCA1 | Lung, colon, liver, brain, testicles | Glioma, lung, testis, liver, colorectal, breast, renal cancer, | H: 21% |
L: 29% | |||
ABCA7 | Bone marrow, brain, kidney, colon, lung pancreas | Melanoma, Lung, cervical, stomach, endometrial, colorectal, pancreatic cancer | H: 38% |
L: 0% | |||
ABCB | |||
ABCB1 | Brain, blood-brain barrier, colon, liver, kidney, testis, placenta, small intestine, pancreas | Ovarian, breast, colon, kidney, adrenocortical cancer, AML | H: 34% |
L: 20% | |||
ABCB4 | Liver | Liver, lung, renal cancer, melanoma | H: 49% |
L: 22% | |||
ABCC | |||
ABCC1 | Kidney, colon, pancreas, lymph nodes, liver, testis, brain, blood-brain barrier, breasts, spleen, | Breast, lung, ovarian or prostate cancer, neuroblastoma | H: 13% |
L: 43% | |||
ABCC2 | Brain, lymph nodes, liver, colon, kidney, lung, testis, breasts, pancreas | Colorectal, liver, lung, gastric cancer | H: 29% |
L: 27% | |||
ABCC3 | Pancreas, liver, lymph nodes, lung, adrenal glands, colon, testis, spleen, small intestine | Pancreatic, liver, lung, colorectal, stomach, renal, breast cancer | H: 13% |
L: 41% | |||
ABCC4 | Brain, testis, colon, kidney adrenal glands, pancreas, liver, ovary, lung, spleen, breasts, skin, heart | Prostate, renal, lung, breast, ovarian, stomach cancer | H: 32% |
L: 23% | |||
ABCC5 | Lymph nodes, pancreas, kidney, testis, brain, colon, liver, heart, muscles | Lung, urothelial, breast, cervical, renal cancer, glioma | H: 34% |
L: 0% | |||
ABCG | |||
ABCG1 | Pancreas, liver, colon, kidney, brain, lung, lymph nodes, testis | Lung, renal, breast, endometrial, prostate, colorectal, cervical, pancreatic cancer, glioma | H: 34% |
L: 0% | |||
ABCG2 | Intestine, testis, colon, placenta, liver, kidney, small intestine | Liver, testis, prostate, renal cancer, glioma | H: 32% |
L: 23% | |||
ABCG4 | Brain, endocrine, testis, colon, liver, kidney | Glioma, melanoma, thyroid, head and neck, renal, testis, ovarian, endometrial cancer | H:43% |
L: 23% |
Table 2 Selected ATP-binding cassette transporters responsible for the development of multi-drug resistance, their experimental inhibitors and drug specificity
ABC transporter | Inhibitor | MDR | Ref. |
ABCB1 | I generation:Cyclosporine A, Verapamil | Daunorubicin, epirobicin, doxorubicin, colchicines, paclitaxel, docetaxel, vincristine, vinblastine, imatinib | [46,145,146,171] |
II generation: Valspodar, zosuquidar | |||
III generation: Tariquidar, OC144-093 | |||
ABCC1 | MK571, probenecid, ibrutinib, 3ATA | Anthracyclines, vinca alkaloids, camptothecins, daunorubicin, imatinib, etoposide, vincristine, vinblastine, methotrexate | [46,145,146,172] |
ABCC2 | Metothrexate, cyclosporine A, fluorescein, MK571 | Doxorubicin, cisplatin, irinotecan, epirubicin, vinblastine | [46,145,146,171,173] |
ABCC3 | Indomethacin, sufinpyrazone, probenecid, benzmromarone | Etoposide, methotrexate, teniposide | [46,145,146,171,173] |
ABCC5 | Curcumin, trequensin, sildenafil | Gemcitabine, methotrexate, 6-mercaptopurine | [46,145,146,171,173] |
ABCG2 | Fumitremorgin C, Ko143, GF120918 | Daunorubicin, doxorubicin, irinotecan, mitoxantrone, methotrexate, epirubicin, etoposide | [46,145,146,171] |
- Citation: Adamska A, Falasca M. ATP-binding cassette transporters in progression and clinical outcome of pancreatic cancer: What is the way forward? World J Gastroenterol 2018; 24(29): 3222-3238
- URL: https://www.wjgnet.com/1007-9327/full/v24/i29/3222.htm
- DOI: https://dx.doi.org/10.3748/wjg.v24.i29.3222