Correlation between serum vitamin B12 level and peripheral neuropathy in atrophic gastritis

Table 1 Comparison of the peripheral nerve conduction velocity of patients with or without peripheral neuropathy

Item	Sensory nerve conduction velocity				Motor nerve conduction velocity
	With peripheral nerve damage	Without peripheral nerve damage	t	P value	With peripheral nerve damage	Without peripheral nerve damage	t	P value
Median nerve	50.10 ± 7.80	52.30 ± 8.90	-2.733	0.006	54.20 ± 8.70	56.20 ± 10.70	-2.129	0.034
Ulnar nerve	49.40 ± 8.10	51.50 ± 9.20	-2.556	0.011	50.30 ± 9.40	51.30 ± 8.60	-1.230	0.219
Tibial nerve	38.30 ± 3.20	44.20 ± 7.60	-9.563	0.000	50.4 ± 8.70	55.60 ± 9.80	-5.931	0.000
Sural nerve	45.40 ± 5.00	50.80 ± 8.30	-7.622	0.000	46.70 ± 7.90	51.10 ± 9.00	-5.479	0.000

Table 2 Comparison of the general situation of patients in the peripheral neuropathy and no peripheral neuropathy groups

Item	Peripheral neuropathy group	No peripheral neuropathy group	t/c2	P value
Age in yr	50.50 ± 13.90	45.00 ± 12.40	4.653	0.000
Sex, % male	50.60	49.50	0.068	0.795
Systolic blood pressure in mmHg	130.17 ± 18.98	128.35 ± 20.32	0.989	0.323
Diastolic blood pressure in mmHg	75.34 ± 10.32	77.02 ± 9.45	-1.880	0.061
BMI in kg/m2	19.26 ± 2.15	21.88 ± 2.27	-12.703	0.000
Gastroscopy results, % prevalence of chronic atrophic gastritis	76.50%	59.20%	15.418	0.000
Helicobacter pylori infection, %	86.40	56.40	46.452	0.000
Gastric acid in mmol	6.80 ± 3.70	17.80 ± 3.50	-33.570	0.000
Serum gastrin in pg/mL	532.42 ± 167.33	208.43 ± 44.12	36.968	0.000
Serum creatinine in μmol/L	78.60 ± 17.20	76.50 ± 12.40	1.643	0.101
VitA in ng/mL	0.267 ± 0.269	0.383 ± 0.336	-3.944	0.000
VitB1 in nmol/L	79.40 ± 20.70	82.60 ± 17.50	-1.884	0.060
VitB6 in mmol/L	30.90 ± 14.80	32.70 ± 15.60	-1.269	0.205
VitB9 in ng/mL	9.06 ± 3.81	10.60 ± 3.27	-2.495	0.013
VitB12 in pg/mL	170.20 ± 111.20	216.40 ± 149.80	-2.731	0.007
VitE in μmol/L	31.60 ± 5.48	33.20 ± 6.37	-1.346	0.181

BMI: Body mass index; Vit: Vitamin.

Table 3 Peripheral neuropathy multivariate logistic regression analysis results

Influencing factor	β	SE	Wald value	OR	95%CI		P value
Age	0.140	0.056	4.658	1.150	1.030	1.283	0.034
BMI	-0.139	2.321	3.097	0.871	0.009	82.261	0.089
Helicobacter pylori infection, infected = 1; uninfected = 0	1.541	0.124	7.816	4.670	3.662	5.955	0.000
Gastric acid	1.332	1.469	1.158	3.790	0.213	67.465	0.886
Serum gastrin	1.545	2.497	1.796	4.690	0.035	626.127	0.375
Endoscopy results, atrophic gastritis = 1; nonatrophic gastritis = 0	1.663	0.197	8.562	5.276	3.586	7.762	0.000
VitA	0.039	0.127	1.562	1.041	0.811	1.334	0.645
VitB9	0.871	0.359	4.162	2.390	1.183	4.830	0.037
VitB12	1.883	0.236	9.364	6.571	4.137	10.434	0.000

BMI: Body mass index; CI: Confidence interval; OR: Odds ratio; SE: Standard error; Vit: Vitamin.

Table 4 Comparison of the general situation of patients with or without vitamin B12 deficiency

Item	VitB12 deficiency, n = 207	Normal VitB12 level, n = 386	t/c2	P value
Age in yr	51.70 ± 14.70	44.3 ± 11.80	6.666	0.000
Sex, % male	51.60	48.80	0.481	0.488
Systolic blood pressure in mmHg	132.13 ± 19.37	129.35 ± 20.06	1.628	0.104
Diastolic blood pressure in mmHg	75.26 ± 11.44	76.31 ± 9.37	-1.202	0.230
BMI in kg/m2	18.36 ± 3.22	22.45 ± 2.39	-17.529	0.000
Helicobacter pylori infection, %	87.6	74.8	12.949	0.000
Gastroscopy results, % prevalence of chronic atrophic gastritis	86.50	51.80	70.180	0.000
Serum creatinine in μmol/L	78.60 ± 17.20	76.5 ± 12.40	1.709	0.088
Gastric acid in mmol	7.90 ± 4.20	17.60 ± 3.50	-29.955	0.000
Serum gastrin in pg/mL	432.85 ± 137.62	219.49 ± 47.98	27.516	0.000

BMI: Body mass index; Vit: Vitamin.

Table 5 Multivariate logistic regression analysis of VitB12 deficiency

Influencing factor	β	SE	Wald value	OR	95%CI		P value
Age	0.519	0.149	4.865	1.680	1.255	2.250	0.023
BMI	1.477	1.325	0.004	4.380	0.326	58.795	0.957
Helicobacter pylori infection, positive = 1; negative = 0	1.730	0.279	7.218	5.640	3.264	9.745	0.000
Endoscopy results, atrophic gastritis = 1; nonatrophic gastritis = 0	2.145	0.364	9.645	8.546	4.187	17.442	0.000
Gastric acid	0.948	1.269	1.024	2.580	0.214	31.032	0.762
Serum gastrin	1.479	2.226	2.549	4.390	0.056	344.567	0.267

BMI: Body mass index; CI: Confidence interval; OR: Odds ratio; SE: Standard error; Vit: Vitamin.

Table 6 Changes in serum VitB12 levels and nerve conduction velocity in patients after half a year of VitB12 supplementation

Item	0 mo	1 mo	2 mo	3 mo	6 mo
VitB12 in pg/mL	158.70 ± 104.50	237.20 ± 156.40	481.50 ± 164.60	614.80 ± 186.70	635.20 ± 174.80
Nerve conduction velocity in m/s at 0 mo	40.10 ± 5.50	40.30 ± 4.70	41.60 ± 7.40	42.70 ± 5.90	45.80 ± 5.80

Vit: Vitamin.