Clinical Trials Study
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 28, 2018; 24(12): 1343-1352
Published online Mar 28, 2018. doi: 10.3748/wjg.v24.i12.1343
Correlation between serum vitamin B12 level and peripheral neuropathy in atrophic gastritis
Guo-Tao Yang, Hong-Ying Zhao, Yu Kong, Ning-Ning Sun, Ai-Qin Dong
Guo-Tao Yang, Hong-Ying Zhao, Yu Kong, Ning-Ning Sun, Ai-Qin Dong, Department of Third Neurology, Cangzhou Central Hospital, Cangzhou Clinical Medical School of Hebei Medical University, Cangzhou 061001, Hebei Province, China
Hong-Ying Zhao, Department of Elderly Internal Medicine, Cangzhou Central Hospital, Cangzhou Clinical Medical School of Hebei Medical University, Cangzhou 061001, Hebei Province, China
Yu Kong, Department of Second Digestion, Cangzhou Central Hospital, Cangzhou Clinical Medical School of Hebei Medical University, Cangzhou 061001, Hebei Province, China
Ning-Ning Sun, Department of First Digestion, Cangzhou Central Hospital, Cangzhou Clinical Medical School of Hebei Medical University, Cangzhou 061001, Hebei Province, China
Author contributions: Yang GT, Zhao HY, Kong Y, Sun NN and Dong AQ designed the research; Yang GT, Zhao HY and Dong AQ performed the research; Yang GT, Zhao HY, Sun NN and Dong AQ contributed new reagents/analytic tools; Yang GT, Zhao HY and Dong AQ analyzed the data; and Yang GT and Dong AQ wrote the paper.
Supported by Cangzhou City Science and Technology Plan Projects, No. 151302138.
Institutional review board statement: The study was reviewed and approved by the Cangzhou Central Hospital, Cangzhou Clinical Medical School of Hebei Medical University Institutional Review Board.
Clinical trial registration statement: This study is registered with the Chinese Clinical Trial Registry, No. ChiCTR-ROC-17014051.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: We declare that there are no conflicts of interest to disclose.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Guo-Tao Yang, MD, Department of Third Neurology, Cangzhou Central Hospital, Cangzhou Clinical Medical School of Hebei Medical University, Gaojiao District, Cangzhou 061001, Hebei Province, China. yangguotao3815@cz_hospital.ac.cn
Telephone: +86-317-2179510 Fax: +86-317-2179510
Received: December 20, 2017
Peer-review started: December 20, 2017
First decision: January 4, 2018
Revised: February 7, 2018
Accepted: February 26, 2018
Article in press: February 26, 2018
Published online: March 28, 2018
Core Tip

Core tip: The general situation and peripheral nerve conduction velocity of 593 patients with chronic gastritis were compared. We found that serum vitamin B12 levels in patients with chronic gastritis significantly decreased, and the occurrence of peripheral neuropathy had a certain correlation. Vitamin B12 supplementation can significantly reduce peripheral nervous system lesions. The occurrence of peripheral neuropathy associated with vitamin B12 deficiency may be considered in patients with chronic atrophic gastritis. Timely supplementation of vitamin B12 during the clinical treatment of chronic atrophic gastritis can reduce or prevent peripheral nervous system lesions.