Clinical Practice Study
Copyright ©The Author(s) 2018.
World J Gastroenterol. Mar 14, 2018; 24(10): 1152-1166
Published online Mar 14, 2018. doi: 10.3748/wjg.v24.i10.1152
Table 1 Prognostic significance of clinicopathological indicators, PGRMC1 and PGRMC2 for disease-free survival in the clinical cohort (n = 89)
FactorDFS univariate
DFS multivariate
GroupHR95%CIP valueHR95%CIP value
Age, yr< 60/≥ 600.9970.609-1.6320.989
SexMale/female1.0140.599-1.7150.960
Viral infection0.825
B/C1.1770.703-1.971
B/B + C1.0680.448-2.547
Child-Pugh score5/≥ 62.4071.346-4.3020.003a2.005(1.097-3.665)0.024a
Cirrhosis-/+0.7430.664-1.7760.299
Serum AFP< 100/≥ 100 ng/ml1.3570.823-2.2380.231
DifferentiationW/M-P1.6820.943-2.9990.078
Multifocal tumor-/+0.9850.514-1.8880.965
Satellite nodule-/+2.1731.303-3.6240.003aNS
Tumor size< 5/≥ 5 cm2.4461.486-4.028< 0.001aNS
Tumor capsular invasion-/+0.9850.545-1.7800.959
Vascular invasion-/+2.5511.553-4.190< 0.001aNS
Liver capsule penetration-/+2.2351.010-4.9450.047aNS
Bile duct invasion-/+3.2000.986-10.3850.053
Margin status, mm≥ 1 /< 13.7932.079-6.920< 0.001a4.720(2.458-9.063)< 0.001a
AJCC stageI-II/ IIIA-C2.9071.738-4.861< 0.001a3.262(1.895-5.617)< 0.001a
PGRMC1H/L1.9181.145-3.2130.013a2.384(1.377-4.128)0.002a
PGRMC2H/L1.3770.798-2.3790.251
ER-/+0.5280.128-2.1730.376
PR-/+0.7770.243-2.4840.670
Table 2 Prognostic significance of clinicopathological indicators, progesterone receptor membrane component 1 and PGRMC2 for disease-free survival in The Cancer Genome Atlas cohort (n = 373)
FactorDFS univariate
DFS multivariate
GroupHR95%CIP valueHR95%CIP value
Age, yr< 60/≥ 601.0190.756-1.3730.903
SexMale/female1.1570.845-1.5850.364
HCC risk factors0.014a< 0.001a
B/NAFLD1.4330.601-3.4140.4172.903(1.130-7.461)0.027a
B/Alcohol1.4490.948-2.2170.0871.002(0.595-1.689)0.993
B/C2.4211.422-4.1210.001a3.368(1.773-6.395)< 0.001a
Child-Pugh scoreA/B-C1.3320.709-2.5040.372
Cirrhosis-/+1.1170.761-1.6410.572
Serum AFP, ng/ml< 100/≥ 1001.0970.752-1.5990.632
Tumor grade2/4/20011.3300.868-2.0380.191
Vascular invasion-/+2.0011.418-2.823< 0.001a3.040(1.889-4.891)< 0.001a
Residual tumor-/+1.7330.938-3.2000.079
AJCC stageI-II/III -IV2.3541.693-3.272< 0.001a1.899(1.107-3.255)0.020a
PGRMC1H/L1.8341.359-2.475< 0.001a2.857(1.781-4.584)< 0.001a
PGRMC2H/L1.2420.923-1.6710.152