Narrow line between benefit and harm: Additivity of hyperthermia to cisplatin cytotoxicity in different gastrointestinal cancer cells

doi:10.3748/wjg.v24.i10.1072

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Mar 14, 2018 (publication date) through Nov 21, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 14, 2018; 24(10): 1072-1083
Published online Mar 14, 2018. doi: 10.3748/wjg.v24.i10.1072

Table 1 Overview of results

Cell line	Effect of temperature at 43 °C on cancer cells viability	IC₅₀ dose of cisplatin	Combined effect of temperature, at 43 °C and IC₅₀ dose of cisplatin on cancer cells viability	Effect of temperature in addition to IC₅₀ dose of cisplatin on cancer cell apoptosis	Effect of temperature on intracellular cisplatin concentration
AGS	↓↓	182	↓	↑	↑↑↑
Caco-2	↓	194	↓↓	-	↑↑
T3M4	-	48	-	↑	↑

The number of the arrows represents strength of effect.

Citation: Cesna V, Sukovas A, Jasukaitiene A, Naginiene R, Barauskas G, Dambrauskas Z, Paskauskas S, Gulbinas A. Narrow line between benefit and harm: Additivity of hyperthermia to cisplatin cytotoxicity in different gastrointestinal cancer cells. World J Gastroenterol 2018; 24(10): 1072-1083
URL: https://www.wjgnet.com/1007-9327/full/v24/i10/1072.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i10.1072