Effects of hydrotalcite combined with esomeprazole on gastric ulcer healing quality: A clinical observation study

Table 1 Comparison of general parameters, Helicobacter pylori positive rate, endoscopic ulcer healing, morphological changes at gastric pits and microvascular networks among the three groups

Group	No.	Gender	Age (yr)	H. pylori positive rate (BT)	H. pylori positive rate (AT)	Total effective rate (AT)	Gastric pits (AT)	Microvascular network changes (AT)
		M/F	(mean ± SD)1	n (%)2	n (%)2	n (%)2	A + B (%)2	Regular (%)2
Healthy control	24	14/10	55.5 ± 12.3				23 (95.8%)	11 (45.8%)
Combination therapy	24	13/114	54.5 ± 11.14	16 (66.7%)4	2 (8.3%)4	23 (95.8)4	22 (91.7%)4	20 (83.3%)3
Monotherapy	24	9/154	53.6 ± 11.24	14 (58.3%)	3 (12.5%)	22 (91.7)	21 (87.5%)	13 (54.2%)

¹ANOVA test was conducted because these data obey normal distributions;

²χ² test was conducted because these data obey χ² distributions;

³P values of post hoc comparison between groups were all lower than 0.05;

⁴P values between groups were higher than 0.05. BT: Before treatment; AT: After treatment; H. pylori: Helicobacter pylori.

Table 2 Comparison of collagen fiber area, collagen I to collagen III ratio, hydroxyproline content, FactorVIII-positive cells and TGF-β1 expression among the three groups by Masson staining, immunohistochemistry, ELISA assay and immunofluorescent imaging

Group	No.	Collagen fiberarea		Collagen I to collagen III ratio		Hydroxyproline content (ng/mL)		FactorVIII-positivecells		TGF-β1expression
		mean ± SD1	P value	mean rank2	P value	mean ± SD1	P value	mean ± SD1	P value	mean ± SD1	P value
Healthy control	24	244679.38 ±	0.0203	38.854	0.0313	1693.72 ±	0.0133	23.25 ± 8.243	0.0003	93984.12 ±	0.0163
		210075.674				419.254				42066.644
Combination therapy (AT)	24	260909.51 ±		39.42		1909.53 ±		33.54 ± 8.72		101163.85 ±
		164713.88				828.78				38130.24
Monotherapy (AT)	24	135700.75 ±		25.963		1235.32 ±		28.58 ± 6.943		72321.44 ±
		94175.383				551.073				20030.293

¹ANOVA test was conducted because these data obey normal distributions;

²Kruskal-Wallis test was conducted because these data did not obey normal distributions;

³P values of post hoc comparison between groups were all lower than 0.05;

⁴P values between combination group and control group were higher than 0.05. AT: After treatment.