Observational Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 21, 2017; 23(7): 1268-1277
Published online Feb 21, 2017. doi: 10.3748/wjg.v23.i7.1268
Effects of hydrotalcite combined with esomeprazole on gastric ulcer healing quality: A clinical observation study
Rui-Qi Yang, Hua Mao, Li-Yun Huang, Pei-Zhu Su, Min Lu
Rui-Qi Yang, Hua Mao, Li-Yun Huang, Pei-Zhu Su, Min Lu, Department of Digestive Diseases, Zhujiang Hospital of Southern Medical University, Guangzhou 510280, Guangdong Province, China
Author contributions: Yang RQ performed the experiments, analyzed data, interpreted the results of the experiments, prepared figures, and drafted the manuscript; Mao H conceived and designed the research; Huang LY performed the experiments and prepared figures; Su PZ performed the experiments and analyzed data; Lu M performed the experiments and interpreted the results of the experiments; all authors have read and approved the final version to be published.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of Zhujiang Hospital of Southern Medical University, Guangzhou, China, approval No. 2014-XHNK-003.
Informed consent statement: All patients gave written informed consent.
Clinical trial registration statement: This study is registered at http://www.chictr.org.cn/usercenter.aspx. The registration identification number is ChiCTR-IPR-16008317.
Conflict-of-interest statement: The authors declared that there is no conflict of interest related to this study.
Data sharing statement: The authors confirm that all data underlying the findings are fully available without restriction. All relevant data are within the paper and its supporting information files.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Hua Mao, Professor, Department of Digestive Diseases, Zhujiang Hospital of Southern Medical University, No. 253, Middle Gongye Avenue, Guangzhou 510280, Guangdong Province, China. maohua1963@126.com
Telephone: +86-13556196250 Fax: +86-13556196250
Received: May 26, 2016
Peer-review started: May 30, 2016
First decision: July 29, 2016
Revised: August 26, 2016
Accepted: September 14, 2016
Article in press: September 14, 2016
Published online: February 21, 2017
Processing time: 269 Days and 21.7 Hours
Core Tip

Core tip: Gastric ulcer is mainly caused by an imbalance in defense mechanisms and injurious factors at the gastric mucosa, and has a high recurrence rate. Previous studies comparing the efficacy of hydrotalcite combined with esomeprazole vs esomeprazole therapy alone for the treatment of gastric ulcer have shown unclear results. In the present study, we conducted a clinical observation study involving 48 patients diagnosed with gastric ulcer treated with either hydrotalcite combined with esomeprazole or esomeprazole alone. The results showed that hydrotalcite combined with esomeprazole was superior to esomeprazole alone in improving gastric ulcer healing quality.