Circulating miR-125a but not miR-125b is decreased in active disease status and negatively correlates with disease severity as well as inflammatory cytokines in patients with Crohn’s disease

Table 1 Demographic and clinical characteristics of active Crohn's disease patients, patients with Crohn's disease in remission, and healthy controls

Parameter	A-CD patients (n = 29)	R-CD patients (n = 37)	HCs (n = 37)	P
Age (yr)	31.38 ± 9.51	31.97 ± 8.86	31.41 ± 5.69	0.941a
Gender (female/male)	17/12	20/17	18/19	0.719a
CRP (mg/L)	45.96 (32.27-67.26)	18.94 (10.78-26.71)	3.99 (3.33-6.06)	< 0.001a
ESR (mm/H)	43.93 (37.46-57.82)	16.73 (11.36-20.40)	13.02 (5.82-15.27)	< 0.001a
CDAI score	206.0 (170.5-253.0)	95.0 (75.5-112.0)	-	< 0.001c
IL-17 (pg/mL)	46.90 (38.46-60.06)	18.07 (10.21-20.17)	-	< 0.001c
TNF-α (pg/mL)	72.77 (53.46-83.39)	22.17 (19.49-30.43)	-	< 0.001c
INF-γ (pg/mL)	33.23 (24.59-39.54)	11.62 (9.16-15.07)	-	< 0.001c

Data are presented as mean ± SD, median (1/4-3/4 quarters), or counts. P < 0.05 was considered significant:

^aComparison among three groups, determined by One-way analysis of variance (ANOVA), Kruskal-Wallis test by ranks, or χ² test;

^cComparison between A-CD and R-CD groups, determined by Wilcoxon signed-rank test. A-CD: Active Crohn's disease; R-CD: Crohn's disease in remission; HCs: Healthy controls; CRP: C reactive protein; ESR: Erythrocyte sedimentation rate; CDAI: Crohn’s disease activity index.