Observational Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 28, 2017; 23(44): 7888-7898
Published online Nov 28, 2017. doi: 10.3748/wjg.v23.i44.7888
Circulating miR-125a but not miR-125b is decreased in active disease status and negatively correlates with disease severity as well as inflammatory cytokines in patients with Crohn’s disease
Chen-Ming Sun, Jie Wu, Heng Zhang, Gan Shi, Zhi-Tao Chen
Chen-Ming Sun, Jie Wu, Heng Zhang, Gan Shi, Zhi-Tao Chen, Department of Gastroenterology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, Hubei Province, China
Author contributions: Sun CM and Wu J contributed to study conception and design; Sun CM contributed to data acquisition, analysis, and interpretation and writing of the article; Wu J, Zhang H, Shi G, and Chen ZT contributed to editing and reviewing the article; all authors read and approved the manuscript.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology.
Informed consent statement: All study participants, or their legal guardian, provided written informed consent prior to study enrollment.
Conflict-of-interest statement: The authors have no conflicts of interest to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Jie Wu, Department of Gastroenterology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, 26 Shengli Street, Wuhan 430014, Hubei Province, China. wujie@zxhospital.com
Telephone: +86-27-82211449 Fax: +86-27-82211449
Received: May 9, 2017
Peer-review started: May 12, 2017
First decision: June 5, 2017
Revised: September 12, 2017
Accepted: September 26, 2017
Article in press: September 26, 2017
Published online: November 28, 2017
Processing time: 201 Days and 8.6 Hours
Core Tip

Core tip: This study aimed to investigate the association of circulating miR-125a/b expression with the risk and severity of Crohn’s disease (CD) and with inflammatory cytokines. Our results showed that miR-125a but not miR-125b is negatively correlated with the risk of active CD and disease severity and with inflammatory cytokines.