Copyright
©The Author(s) 2017.
World J Gastroenterol. Aug 21, 2017; 23(31): 5809-5816
Published online Aug 21, 2017. doi: 10.3748/wjg.v23.i31.5809
Published online Aug 21, 2017. doi: 10.3748/wjg.v23.i31.5809
Table 1 Characteristics of the 67 donation after cardiac death donors n (%)
Characteristic | Value |
Age in years, median (IQR) | 29.0 (19.0-44.0) |
Sex | |
Male | 55 (82.1) |
Female | 12 (17.9) |
Origin of death | |
HT | 31 (46.3) |
Benign CNS tumor | 18 (26.9) |
CVA | 15 (22.4) |
Anoxia | 2 (3.0) |
Meningitis | 1 (1.5) |
China classification of donation | |
I | 5 (7.5) |
II | 8 (11.9) |
III | 54 (80.6) |
ICU stay in days, median (IQR) | 5 (3.0-10.0) |
Donors with positive culture | 13 |
Blood culture, n/n | |
Donors with/without available results | 53/14 |
Donors with appropriate antimicrobial use/all donors with positive blood culture results | 10/13 |
Table 2 Classification and percentage of organisms isolated from donors' bloodstream, n = 17
Organism | n (%) |
Gram-positive bacteria | 12 (70.6) |
Staphylococcus aureus | 3 (17.6) |
Coagulase-negative staphylococci | 9 (52.9) |
S. epidermidis | 4 (23.5) |
S. hemolyticus | 1 (5.9) |
S. capitis | 1 (5.9) |
S. hominis | 2 (11.8) |
S. simulans | 1 (5.9) |
Gram-negative bacteria | 3 (17.6) |
Klebsiella pneumoniae | 2 (11.8) |
Acinetobacter baumannii | 1 (5.9) |
Fungi | 2 (11.8) |
Candida albicans | 1 (5.9) |
Candida parapsilosis | 1 (5.9) |
Table 3 Characteristics of donors and their corresponding liver recipients with donor-derived infections
Donor | Diagnosis | Blood culture result | Recipient (sex/age) | Underlying liver disease(s) | Culture result (specimen)/time to infection onset | Inappropriate antimicrobial/immunosuppressive therapy | Outcome |
D1 | Head trauma | Negative1 | R12 (Female/48 yr) | Polycystic liver disease | K. pneumoniae (Blood and abdominal drainage fluid)/1 d | No/Pred | Patient death and graft loss |
D2 | Head trauma | Negative1 | R23 (Male/38 yr) | Hepatocellular carcinoma and cirrhosis due to hepatitis B virus infection | K. pneumoniae (Blood and abdominal drainage fluid)/1 d | No/FK506 + Pred | Patient and graft survival |
D3 | Head trauma | Not available | R33 (Male/69 yr) | Heredofamilial amyloidosis | E. aerogenes (Blood)/3 d | No/FK506 + Pred | Patient and graft survival |
Table 4 Comparison of post-liver-transplant complications in liver recipients with and without donor-derived infections
Complication | Episodes of complications in three liver recipients with donor-derived infections | Episodes of complications in 64 liver recipients without donor-derived infections |
Infection | 4 | 16 |
Pneumonia | 1 | 7 |
Peritonitis | 0 | 3 |
Bloodstream infection | 3 | 5 |
Surgical site infection | 0 | 1 |
Vascular complications | 0 | 9 |
Portal vein thrombosis | 0 | 1 |
Cerebral embolism | 0 | 1 |
Hepatic artery thrombosis | 0 | 1 |
Abdominal bleeding | 0 | 5 |
Gastrointestinal bleeding | 0 | 1 |
Biliary complications | 3 | 2 |
Bile leakage | 0 | 0 |
Biliary strictures | 1 | 2 |
Stone formation | 1 | 0 |
Bilomas | 1 | 0 |
Recurrent tumor | 0 | 6 |
Acute rejection | 0 | 4 |
Graft-versus-host disease | 0 | 2 |
Graft dysfunction | 0 | 3 |
Adhesive ileus | 0 | 1 |
- Citation: Ye QF, Zhou W, Wan QQ. Donor-derived infections among Chinese donation after cardiac death liver recipients. World J Gastroenterol 2017; 23(31): 5809-5816
- URL: https://www.wjgnet.com/1007-9327/full/v23/i31/5809.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i31.5809