Prospective Study
Copyright ©The Author(s) 2017.
World J Gastroenterol. May 28, 2017; 23(20): 3721-3729
Published online May 28, 2017. doi: 10.3748/wjg.v23.i20.3721
Table 1 Proliferating cell nuclear antigen and E-cadherin labeling indexes in normal gastric tissues and diseased tissues
Tissue typeNumber of casesPCNA labeling indexE-cadherin labeling index
Normal gastric tissue401.37 ± 0.3222.34 ± 6.23
Intestinal metaplasia3811.53 ± 3.3813.92 ± 4.34
Dysplasia4214.34 ± 4.717.84 ± 2.08
Gastric cancer6644.50 ± 9.851.68 ± 0.47
F-value-4.1705.181
P-value-0.0180.002
Comparison of gastric cancer and dysplasia
Q-value-18.51923.204
P-value0.0000.000
Table 2 Proliferating cell nuclear antigen and E-cadherin expression in the two groups
GroupNo. of casesPCNA
E-cadherin
-++++++-++++++
Normal group4029641515119
Gastric cancer group6616111722451173
Z-value--5.231-4.982
P-value-0.0000.000
Table 3 Relationship between proliferating cell nuclear antigen and E-cadherin expression and clinicopathological characteristics of gastric cancer patients
Clinicopathological characteristicNo. of casesPCNA
E-cadherin
PositiveP valuePositiveP value
Gender0.0730.340
Male453716
Female21135
Age (yr)0.3190.140
≥ 60403210
< 60261811
Lymph node metastasis0.0390.000
Yes42367
Non241414
Degree of differentiation0.2780.065
Medium and low differentiation423010
High differentiation242011
T stage0.0030.568
T1/T225149
T3/T4413612
Table 4 Analysis of clinicopathological factors that influence the prognosis of patients with gastric cancer
VariableLog-rank univariate analysisCox regression multivariate analysis
P valueP valueRR (95%CI)
Gender0.285--
Age0.128--
Lymph node metastasis0.0000.0554.369 (0.967-19.733)
Degree of differentiation0.268--
T stage0.0040.00017.556 (5.343-57.680)
PCNA0.0030.00028.786 (5.088-162.853)
E-cadherin0.0210.0050.174 (0.051-0.598)
Table 5 Evaluation of gastric cancer patient survival by proliferating cell nuclear antigen and E-cadherin
IndicatorsSurvival time <3 yrSurvival time >3 yrSensitivitySpecificityAccuracy
PCNA93.33%38.89%0.64
Positive2822
Negative214
E-cadherin80.0%41.67%0.59
Positive615
Negative2421
The combination of both (PCNA[+] and E-cadherin[-])80.0%66.67%0.73
Positive2412
Negative624