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©The Author(s) 2017.
World J Gastroenterol. May 7, 2017; 23(17): 3066-3076
Published online May 7, 2017. doi: 10.3748/wjg.v23.i17.3066
Published online May 7, 2017. doi: 10.3748/wjg.v23.i17.3066
Table 1 Demographic and clinical characteristics of study participants
Characteristics | Elevated cohort, n = 24 (%) | Polypoid cohort, n = 23 (%) | P value |
Age, mean ± SD | 54.1 ± 9.4 | 53.9 ± 9.4 | > 0.05 |
Sex (male/female) | 13/11 | 11/12 | > 0.05 |
BMI, mean ± SD | 23.8 (3.2) | 23.9 (3.3) | > 0.05 |
Smoker (yes/no) | 9/15 (38/62) | 9/14 (39/61) | > 0.05 |
Excess alcohol (yes/no) | 3/24 (13) | 3/23 (13) | > 0.05 |
Lesion site (prox/dist/rect) | 16/5/3 (67/21/12) | 6/9/8 (26/39/35) | < 0.05 |
Diameter (mm), mean (range) | 8 (2-50) | 9 (3-32) | > 0.05 |
Paris classification | 0-IIa, 24 (100) | 0-I, 23 (100) | < 0.05 |
Histology, T/TV/V/S | 14/8/2/0 (58/33/8/0) | 11/9/3/0 (48/39/13/0) | > 0.05 |
Pathological grade | Low-grade, 24 (100) | Low-grade, 23 (100) | > 0.05 |
Table 2 Spearman correlation analysis of the molecular characteristics of colorectal adenomas
Characteristic 1 | Characteristic 2 | Spearman correlation coefficient (ρ) | P value |
β-catenin protein expression | β-catenin-TCF/LEF-driven transcriptional activity | 0.83 | < 0.05 |
β-catenin-TCF/LEF-driven transcriptional activity | C-Myc protein expression | -0.78 | < 0.05 |
β-catenin-TCF/LEF-driven transcriptional activity | Cyclin D1 protein expression | 0.79 | < 0.05 |
Cyclin D1 protein expression | C-Myc protein expression | -0.74 | < 0.05 |
C-Myc protein expression | Bcl-2 protein expression | -0.74 | < 0.05 |
C-Myc protein expression | Bcl-xL protein expression | -0.78 | < 0.05 |
- Citation: Yang TW, Gao YH, Ma SY, Wu Q, Li ZF. Low-grade slightly elevated and polypoid colorectal adenomas display differential β-catenin-TCF/LEF activity, c-Myc, and cyclin D1 expression. World J Gastroenterol 2017; 23(17): 3066-3076
- URL: https://www.wjgnet.com/1007-9327/full/v23/i17/3066.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i17.3066