Importance of antimicrobial susceptibility testing for the management of eradication in Helicobacter pylori infection

Table 1 Summary of studies compared eradication rates of susceptible guided with emprical threapy for the first line eradication regimen

Ref.	Methods	Type of therapy		Patient number (n)		Eradication rates; ITT/PP (%)
		SGT	Empirical therapy	SGT	Empirical therapy	SGT	Empirical therapy
Dong et al[73], 2015	E-test	Bismuth Quadruple Therapy (RpzBAC, RpzBAL, RpzBAF, RpzBAM, RpzBCM)	Quadruple Therapy (RpzBAC)	45	45	91.1/95.3	73.3/78.6
Park et al[87], 2014	Agar dilüsyon	P AC, PAM, PAL	PAC	57	57	94.7/96.4	71.9/73.2
Martos et al[82], 2014	E-test	OAC, OAM, OAL	OAC	55	50	94/94	67/72
Cosme et al[84], 2015	E-test	OAL, OAM, OAC	CT = OACM	122	181	94.2/95.1	87.2/88.7
Cosme et al[26], 2012	E-test	OAC, OBMT, OAL, OAM, OAR, OAD	OAC, OAM, OAL, OML, OMC	134	113	NR/88	NR/49
Zhou et al[92],2015	E-test	Rpz/EAC, Rpz/EATz	CT = EACTz,	350	350 TTB	88.7/93.3	77.4/87(TTB)
			TTB = BEAC		350 CT		78.3/87.4(CT)
Lee et al[88], 2013	PCR	RpzAC, RpzAM	RpzAC, RpzAM	218	616	80.7/91.2	69.5/75.9 (RpzAC)
							71.1/79.1 (RpzAM)

ITT: Intention-to-treat; PP: Per protocol; O: Omeprazole; Rpz: Rabeprazole; P: Pantoprazole; L: Lansoprazole; E: Esomeprazole; C: Clarithromycin; A: Amoxicillin; L: Levofloxacin; F: Furazolidone; R: Rifabutin; D: Doxycycline; Tz: Tinidazole; T: Tetracycline; B: Bismuth; CT: Concomitant therapy; TTB: Triple therapy plus bismuth; M: Metronidazole; NR: Not reported.

Table 2 Eradication rates achieved with susceptible guided therapy as first treatment and rescue treatment

Line of therapy	Ref.	Type of therapy	Patients (n)	Methods	Tailored therapy eradication rates
					ITT %	PP %
First Line	Liu et al[83], 2015	RpzBAC, RpzBAF	89	Real-time PCR	98 in RpzBAC group	100 in RpzBAC group
					92.6 in RpzBAF group	94 in RpzBAF group
First Line	Sugimoto et al[90], 2014	RpzAC, RpzAM	153	PCR	96.7 (overall)	97.4 (overall)
Third line	Liou et al[89], 2013	Sequential triple	135	PCR and Agar dilution	80.7	82.6
Fourth	Fiorini et al[91], 2013	Triple (EAC, EAR)	236	E-test	NR	90 in EAC
						88.6 in EAR

B: Bismuth potassium citrate; Rpz: Rabeprazole; A: Amoxicillin; C: Clarithromycin; F: Furazolidone; M: Metronidazole; R: Rifabutin; E: Esomeprazole; NR: Not reported.