Published online Apr 28, 2017. doi: 10.3748/wjg.v23.i16.2854
Peer-review started: October 29, 2016
First decision: November 21, 2016
Revised: February 6, 2017
Accepted: March 30, 2017
Article in press: March 30, 2017
Published online: April 28, 2017
Core tip: Eradication failure is of great importance in Helicobacter pylori (H. pylori) infection. Antibiotic resistance in H. pylori is widespread and increasing. Therefore, understanding antimicrobial resistance mechanisms and detecting H. pylori antimicrobial susceptibility are important for guiding eradication regimens before the initiation of first-line therapy or alternative regimens for patients in whom repeated eradication therapies have failed. This manuscript presents an overview of the mechanisms of antimicrobial resistance and the methods that have been developed for the detection of resistance. It also highlights the contribution of antimicrobial susceptibility testing to the management of H. pylori eradication therapy.