Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 28, 2017; 23(16): 2854-2869
Published online Apr 28, 2017. doi: 10.3748/wjg.v23.i16.2854
Importance of antimicrobial susceptibility testing for the management of eradication in Helicobacter pylori infection
Nazlı Arslan, Özlem Yılmaz, Ebru Demiray-Gürbüz
Nazlı Arslan, Özlem Yılmaz, Ebru Demiray-Gürbüz, Department of Medical Microbiology, Faculty of Medicine, Dokuz Eylül University, Inciraltı, Izmir 35340, Turkey
Author contributions: Arslan N, Yılmaz Ö and Demiray-Gürbüz E contributed to this paper.
Conflict-of-interest statement: Arslan N, Yılmaz Ö and Demiray-Gürbüz E declare no conflicts of interest related to this publication.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Özlem Yılmaz, PhD, Professor, Department of Medical Microbiology, Faculty of Medicine, Dokuz Eylül University, Inciraltı, Izmir 35340, Turkey.
Telephone: + 90-232-4124506 Fax: + 90-232-4129798
Received: October 27, 2016
Peer-review started: October 29, 2016
First decision: November 21, 2016
Revised: February 6, 2017
Accepted: March 30, 2017
Article in press: March 30, 2017
Published online: April 28, 2017
Core Tip

Core tip: Eradication failure is of great importance in Helicobacter pylori (H. pylori) infection. Antibiotic resistance in H. pylori is widespread and increasing. Therefore, understanding antimicrobial resistance mechanisms and detecting H. pylori antimicrobial susceptibility are important for guiding eradication regimens before the initiation of first-line therapy or alternative regimens for patients in whom repeated eradication therapies have failed. This manuscript presents an overview of the mechanisms of antimicrobial resistance and the methods that have been developed for the detection of resistance. It also highlights the contribution of antimicrobial susceptibility testing to the management of H. pylori eradication therapy.