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©The Author(s) 2017.
World J Gastroenterol. Mar 28, 2017; 23(12): 2185-2193
Published online Mar 28, 2017. doi: 10.3748/wjg.v23.i12.2185
Published online Mar 28, 2017. doi: 10.3748/wjg.v23.i12.2185
Table 1 Characteristics of patients with autoimmune pancreatitis and autoimmune pancreatitis + pancreatic cancer n (%)
AIP without PC | AIP with PC | P value | |
Total | 9 (60) | 6 (40) | |
AIP type 1 | 4 (44) | 2 (33) | |
AIP type 2 | 5 (56) | 4 (67) | |
Sex (males) | 6 (67) | 6 (100) | |
Age | 49 (35-64) | 60.5 (54-67) | 0.045 |
Smoking | 5 (56) | 4 (67) | |
Recent onset of diabetes mellitus | 1 (11) | 4 (67) | 0.090 |
History of another autoimmune disorder | 4 (44)1 | 0 | |
History of pancreatic disease | 5 (56)2 | 1 (17)3 | |
Jaundice | 3 (33) | 4 (67) | |
Weight loss | 6 (67) | 6 (100) | |
in kilograms | 8.5 (3-12) | 15.5 (8-50) | 0.030 |
Location of lesion (head of the pancreas) | 8 (89) | 5 (83) | |
Ca 19-9 (normal range 0-27 kU/L) | 35.2 (2.5-300) | 89.8 (19.8-110) |
Table 2 Histopathology findings in patients with type 1 autoimmune pancreatitis + pancreatic cancer
Patient | Sex | Age | Periductal lymphoplasmacytic infiltrate without granulocytic infiltration | Obliterative phlebitis | Storiform fibrosis | IgG4-positive cells |
2 | M | 67 | Yes | Yes | Yes | 47/HPF |
6 | M | 61 | Yes | Yes | Yes | 58/HPF |
Table 3 Histopathology findings in patients with type 2 autoimmune pancreatitis + pancreatic cancer
Patient | Sex | Age | Granulocytic infiltration of duct wall (GEL) | Granulocytic and lymphoplasmacytic acinar infiltrate | IgG4-positive cells |
1 | M | 54 | Yes | 4/HPF | |
3 | M | 63 | Yes | 2/HPF | |
4 | M | 58 | Yes | 7/HPF | |
5 | M | 60 | Yes | 4/HPF |
Table 4 Serum IgG4, imaging methods and fine needle aspiration biopsy results in patients with autoimmune pancreatitis and autoimmune pancreatitis + pancreatic cancer
Sex | Age | Serum IgG4 (mg/dL) | CT | ERP | EUS | EUS-FNA | |
AIP type 1 + PC | M | 67 | N/A | A | N/A | N/A | N/A |
M | 61 | N/A | A | CBD stricture; no wirsungography | Susp M | Inconclusive | |
AIP type 1 | M | 46 | 81.5 | L2 | CBD stricture; no wirsungography | Ambigious | Negative |
M | 57 | 81.5 | A | CBD stricture; no wirsungography | N/A | N/A | |
M | 49 | N/A | A | Unsuccesful attempt for wirsungography | Cystic tumour; signs of CHP | Inconclusive | |
M | 48 | 23.1 | L2 | N/A | Susp M | Negative | |
AIP type 2 + PC | M | 54 | NR | L2 | N/A | Ambigious | Susp M |
M | 63 | NR | A | N/A | Ambigious | Susp M | |
M | 58 | NR | A | Wirsungolithiasis | N/A | N/A | |
M | 60 | NR | A | N/A | Ambigious | Susp M | |
AIP type 2 | F | 61 | NR | L2 | N/A | Susp M | Susp M |
F | 64 | NR | A | Dilated PD; mucous secretion | Susp MD-IPMN | Negative | |
M | 35 | NR | L2 | N/A | ambigious | Susp M | |
F | 47 | NR | L2 | N/A | ambigious | Negative | |
M | 53 | NR | A | N/A | N/A | N/A |
- Citation: Macinga P, Pulkertova A, Bajer L, Maluskova J, Oliverius M, Smejkal M, Heczkova M, Spicak J, Hucl T. Simultaneous occurrence of autoimmune pancreatitis and pancreatic cancer in patients resected for focal pancreatic mass. World J Gastroenterol 2017; 23(12): 2185-2193
- URL: https://www.wjgnet.com/1007-9327/full/v23/i12/2185.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i12.2185