Copyright
©The Author(s) 2017.
World J Gastroenterol. Mar 28, 2017; 23(12): 2095-2105
Published online Mar 28, 2017. doi: 10.3748/wjg.v23.i12.2095
Published online Mar 28, 2017. doi: 10.3748/wjg.v23.i12.2095
Table 1 Recipient characteristics at the time of liver transplantation
Case | Age | Gender | AB0 | BMI | Indication | Real MELD | MELD correct | UNOS | Wating List(d) | Year LT | HCC criteria | Downstaging type (No.) |
1 | 62 | M | 0 | 27 | HCC/HBV | 26 | 36 | 2A | 37 | 2007 | MILAN IN | LOC(1)1 |
2 | 65 | M | B | 21 | HCC/HBV | 16 | 39 | 3 | 522 | 2007 | MILAN IN | LOC(1) + SUR(1) |
3 | 54 | M | A | 22 | HCC/HBV | 10 | 33 | 3 | 513 | 2007 | MILAN IN | LOC(1) |
4 | 45 | M | A | 24 | HCC/HBV | 14 | 34 | 2B | 419 | 2007 | MILAN OUT | LOC (3) |
5 | 62 | M | 0 | 29 | HCC/HBV | 12 | 33 | 3 | 445 | 2008 | MILAN OUT | LOC (2) |
6 | 53 | M | 0 | 28 | HCC/HBV | 12 | 35 | 2B | 515 | 2008 | MILAN IN | LOC (1) |
7 | 45 | M | A | 23 | HCV/HBV | 24 | 24 | 2A | 101 | 2005 | ||
8 | 64 | M | B | 27 | HBV/HCV | 33 | 33 | 2A | 478 | 2005 | ||
9 | 26 | M | A | 23 | HBV | 23 | 23 | 2B | 742 | 2005 | ||
10 | 64 | M | A | 22 | HCC/HBV | 11 | 23 | 2B | 144 | 2005 | MILAN IN | LOC (2) |
11 | 65 | F | B | 25 | HCC/HBV | 12 | 24 | 2A | 195 | 2006 | MILAN IN | LOC (2) |
12 | 56 | M | A | 24 | HCC/HBV | 10 | 24 | 2B | 217 | 2006 | MILAN OUT | LOC (5) |
13 | 61 | F | 0 | 23 | HCC/HBV | 14 | 30 | 2B | 352 | 2006 | MILAN IN | LOC (2) |
14 | 59 | M | A | 24 | HBV | 30 | 30 | 2B | 118 | 2007 | ||
15 | 48 | F | A | 27 | CBS | 21 | 33 | 2A | 82 | 2007 | ||
16 | 65 | M | A | 24 | HCC/HBV | 8 | 25 | 2B | 358 | 2009 | MILAN IN | LOC (2) |
17 | 57 | M | A | 30 | HCC/HBV | 14 | 39 | 2B | 576 | 2009 | MILAN OUT | LOC (7) |
18 | 55 | M | B | 28 | HCC/HBV | 18 | 26 | 2B | 38 | 2009 | MILAN IN | LOC (3) |
19 | 65 | M | A | 24 | HCC/HBV | 7 | 25 | 2B | 371 | 2009 | MILAN IN | LOC (3) |
20 | 63 | M | A | 28 | HCC/HBV | 16 | 25 | 2B | 1962 | 2010 | MILAN IN | LOC (2) |
21 | 60 | M | A | 34 | HCC/HBV | 10 | 27 | 2B | 330 | 2010 | MILAN OUT | LOC (1) + SUR (1) |
22 | 61 | M | A | 24 | HBV | 11 | 11 | 3 | 855 | 2010 | ||
23 | 67 | M | 0 | 19 | HBV | 16 | 16 | 2B | 742 | 2004 | ||
24 | 55 | M | A | 24 | HBV | 17 | 17 | 3 | 127 | 2004 | ||
25 | 60 | F | 0 | 29 | HBV/HCV | 17 | 17 | 2B | 961 | 2004 | ||
26 | 55 | M | A | 26 | HCC/HBV | 10 | 20 | 3 | 748 | 2005 | MILAN IN | LOC (1) |
27 | 54 | M | A | 27 | HCC/HBV | 13 | 19 | 3 | 134 | 2006 | MILAN OUT | LOC (2) |
28 | 67 | M | 0 | 22 | HCC/HBV | 12 | 29 | 3 | 575 | 2009 | MILAN IN | LOC (1) + SUR (1) |
Table 2 Recipient characteristics n (%)
Recipient variables | n = 28 |
Transplant center (No. of patients) | |
Modena | 6 (21.4) |
Bologna | 16 (57.1) |
Padova | 6 (21.4) |
Gender | |
Male | 24 (85.7) |
Female | 4 (14.3) |
AB0 blood group | |
Isogroup | 28 (100) |
0 | 7 (25) |
A | 17 (60.7) |
B | 4 (14.3) |
Age (yr), mean (range, SD) | 57.6 (26-67, ± 8.7) |
Body mass index, mean (range, SD) | 25.3 (19-34, ± 3.1) |
Real MELD score, mean (range, SD) | 15.6 (7-33, ± 6.5) |
Correct MELD score, mean (range, SD) | 26.7 (11-39, ± 7.2) |
UNOS status | |
2A | 5 (17.5) |
2B | 15 (53.6) |
3 | 8 (28.6) |
Time waiting list (d), mean (range, SD) | 452 (37-1962, ± 393.5) |
Associated hepatocellular carcinoma | 19 (69.7) |
Meeting Milan criteria | 13 (46.4) |
Meeting UCSF criteria | 6 (21.4) |
HBsAg status | |
Positive | 23 (82.1) |
Negative | 5 (17.9) |
HBV DNA positive at LT | 12 (52.1) |
HCV co-infection | 4 (14.3) |
HDV co-infection | 0 |
Table 3 Donor characteristics
Case | Age | Gender | AB0 Gr. | BMI (kg/m2) | Cause of death | Time ICU (d) | Sodium (mEq/mL) | Vasopressors | Histologic activity index | Graft steatosis macro | |
Grading | Staging | ||||||||||
1 | 59 | M | 0 | 26 | CH | 2 | 165 | No | 1 | 0 | 20% |
2 | 13 | F | B | 19 | T | 21 | 161 | Yes | 2 | 0 | 0% |
3 | 69 | M | A | 24 | CH | 3 | 152 | No | 0 | 0 | 0% |
4 | 72 | F | A | 27 | CH | 7 | 150 | No | 1 | 0 | 35% |
5 | 66 | M | 0 | 22 | CH | 5 | 137 | Yes | 3 | 1 | 0% |
6 | 60 | M | 0 | 26 | CH | 4 | 158 | No | 2 | 0 | 0% |
7 | 73 | M | A | 26 | CH | 2 | 151 | Yes | 2 | 1 | 0% |
8 | 51 | M | B | 23 | CH | 6 | 149 | Yes | 3 | 1 | 10% |
9 | 54 | M | A | 24 | T | 13 | 160 | Yes | 2 | 1 | 10% |
10 | 72 | F | A | 23 | T | 2 | 148 | No | 2 | 0 | 0% |
11 | 60 | F | B | 29 | CH | 8 | 162 | Yes | 3 | 1 | 5% |
12 | 65 | M | A | 29 | CH | 3 | 140 | Yes | 4 | 1 | 30% |
13 | 50 | M | 0 | 24 | CH | 12 | 141 | Yes | 2 | 1 | 3% |
14 | 48 | M | A | 23 | T | 2 | 143 | No | 4 | 1 | 5% |
15 | 26 | M | A | 23 | T | 1 | 145 | Yes | 1 | 0 | 0% |
16 | 52 | F | A | 28 | CH | 1 | 155 | Yes | 4 | 1 | 0% |
17 | 79 | F | A | 24 | CH | 19 | 136 | No | 0 | 0 | 0% |
18 | 46 | F | B | 29 | CH | 2 | 158 | No | 0 | 0 | 0% |
19 | 61 | M | A | 29 | CH | 3 | 156 | No | 1 | 1 | 10% |
20 | 53 | F | A | 25 | CH | 6 | 154 | Yes | 2 | 1 | 4% |
21 | 44 | F | A | 24 | CH | 6 | 144 | Yes | 4 | 1 | 5% |
22 | 23 | F | A | 21 | other | 7 | 149 | Yes | 1 | 1 | 0% |
23 | 57 | F | 0 | 24 | CH | 4 | 147 | Yes | 0 | 0 | 0% |
24 | 59 | M | A | 24 | CH | 1 | 160 | Yes | 0 | 0 | 5% |
25 | 35 | F | 0 | 23 | CH | 1 | 140 | Yes | 1 | 0 | 0% |
26 | 36 | M | A | 25 | T | 2 | 146 | Yes | 3 | 1 | 0% |
27 | 23 | M | A | 29 | T | 2 | 147 | Yes | 0 | 0 | 0% |
28 | 66 | F | 0 | 27 | CH | 3 | 151 | Yes | 1 | 0 | 10% |
Table 4 Serological state of the recipient/donor
Case | HBsAg | HBsAb | HBcAb | HBeAg | HBeAb | HBV DNA | HDV | HDV RNA | HCV Ab | Therapy pre-LT | Mutation |
R1 | + | - | + | - | + | - | - | - | - | Lam | No |
D1 | + | - | + | - | + | + | - | - | - | No | - |
R2 | + | - | + | - | + | - | - | - | - | Lam | No |
D2 | + | - | + | - | + | + | - | - | - | No | - |
R3 | + | - | + | - | + | + | - | - | - | Lam + Adef | Yes |
D3 | + | - | + | - | + | + | - | - | - | No | - |
R4 | + | - | + | + | - | - | - | - | - | Lam | No |
D4 | + | - | + | - | + | - | - | - | - | No | - |
R5 | + | - | + | - | + | + | - | - | - | Lam + Adef | Yes |
D5 | + | - | + | - | + | - | - | - | - | No | - |
R6 | + | - | + | - | + | - | + | - | - | Lam | No |
D6 | + | - | + | - | + | + | - | - | - | No | - |
R7 | - | + | + | - | - | - | - | - | + | No | No |
D7 | + | - | + | + | - | + | - | - | + | No | - |
R8 | - | + | + | - | - | - | - | - | + | No | No |
D8 | + | - | + | - | + | + | - | - | - | No | - |
R9 | + | - | + | + | - | + | - | - | - | Lam | No |
D9 | + | - | + | + | - | + | - | - | - | No | - |
R10 | + | - | + | - | + | - | - | - | - | Lam | No |
D10 | + | - | + | + | - | + | - | - | - | No | - |
R11 | - | + | + | - | - | - | - | - | + | No | No |
D11 | + | - | + | + | - | + | - | - | + | No | - |
R12 | + | + | + | - | + | + | - | - | - | Lam | No |
D12 | + | - | + | - | + | + | - | - | - | No | - |
R13 | + | - | + | - | + | - | - | - | - | Lam | No |
D13 | + | - | + | + | - | + | - | - | - | No | - |
R14 | + | - | + | - | + | + | - | - | - | Lam | No |
D14 | + | - | + | - | + | - | - | - | - | No | - |
R15 | - | - | + | - | + | - | - | - | - | No | No |
D15 | + | - | + | - | + | + | - | - | - | No | - |
R16 | + | - | + | - | + | + | - | - | - | Lam | No |
D16 | + | - | + | - | + | + | - | - | - | No | - |
R17 | + | - | + | - | + | + | - | - | - | Lam + Adef | Yes |
D17 | + | - | + | + | - | + | - | - | - | No | - |
R18 | + | - | + | - | + | + | - | - | - | Lam | No |
D18 | + | - | + | - | + | - | - | - | - | No | - |
R19 | + | - | + | + | - | + | - | - | - | Adefovir | No |
D19 | + | - | + | + | - | + | - | - | - | No | - |
R20 | + | - | + | - | + | + | - | - | - | Lam + Adef | No |
D20 | + | - | + | + | - | + | - | - | - | No | - |
R21 | + | - | + | - | + | - | - | - | - | NA | No |
D21 | + | - | + | + | - | + | - | - | - | No | - |
R22 | + | - | + | - | + | - | - | - | - | Lam | No |
D22 | + | - | + | + | - | + | - | - | - | No | - |
R23 | + | - | + | - | + | - | - | - | - | Lam | No |
D23 | + | - | + | - | + | - | - | - | - | No | - |
R24 | + | - | + | - | + | + | - | - | - | Lam | Yes |
D24 | + | - | + | - | + | - | - | - | - | No | - |
R25 | - | + | + | - | + | - | - | - | + | No | No |
D25 | + | - | + | - | + | - | - | - | - | No | - |
R26 | + | - | + | - | + | - | - | - | - | Lam | No |
D26 | + | - | + | + | - | + | - | - | - | No | - |
R27 | + | - | + | - | + | - | - | - | - | Adef | Yes |
D27 | + | - | + | - | + | + | - | - | - | No | - |
R28 | + | - | + | - | + | - | + | - | - | Lam | No |
D28 | + | - | + | + | - | + | - | - | - | No | - |
Table 5 Literature review
- Citation: Ballarin R, Cucchetti A, Russo FP, Magistri P, Cescon M, Cillo U, Burra P, Pinna AD, Di Benedetto F. Long term follow-up and outcome of liver transplantation from hepatitis B surface antigen positive donors. World J Gastroenterol 2017; 23(12): 2095-2105
- URL: https://www.wjgnet.com/1007-9327/full/v23/i12/2095.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i12.2095