Ombitasvir, paritaprevir, ritonavir, dasabuvir and ribavirin in cirrhosis after complete destruction of hepatocellular carcinoma

Table 1 Laboratory findings in case 1

	BL	Week 1	Week 2	Week 4	Week 8	Week 12 (ETR)	Week 12 post therapy (SVR-12)	Week 24 post therapy (SVR-24)
Hgb (g/L)	106	107	97	85	79	89	105	111
WBC (G/L)	3.2	2.4	3.7	5.8	5.3	3.5	4.5	4.7
PLT (G/L)	80	69	111	123	136	94	81	91
TBil/DBil (μmol/L)	16/10	98/47	66/34	41/25	42/9	13/7	10/5	12/5
ALT (U/L)	49	28	20	23	25	15	11	15
Alb (g/L)	39	39	42	41	36	38	44	44
PT (s)	14.4	14.2	14.9	15.8	14.5	15.1	14.2	15.3
HCV RNA (IU/mL)	496183		UND	UND		UND	UND	UND
FIBROMAXTM	A2/F4					A0/F4
TBA (μmol/L)	27					39	33.5

BL: Treatment baseline; ETR: End of treatment response; SVR-12: Sustained virological response 12 wk post therapy; SVR-24: Sustained virological response 24-wk post therapy; UND: Undetectable; Hgb: Hemoglobin; WBC: White blood cell count; PLT: Platelet count; TBil: Total bilirubin; DBil: Direct bilirubin; ALT: Alanine aminotransferase; Alb: Albumin; PT: Prothrombin time; HCV: Hepatitis C virus; TBA: Total bile acids.

Table 2 Dynamic of alpha fetoprotein levels in case 1

	Aug 2013	Nov 2013	Mar 2014	Jun 2014	Aug 2014	Oct 2014	Jan 2015	Apr 2015	Jul 2015	Oct 2015
AFP (ULN < 5.5 IU/mL)	15	14	19	13	13	20	77	4	4.05	4.36

ULN: Upper limit of normal; AFP: Alpha fetoprotein.

Table 3 Alterations of alpha fetoprotein levels in case 2

	Apr 2012	July 2012	Aug 2012	Sep 2012	Feb 2012	Sep 2013	Apr 2014	Jan 2015	Apr 2015	Jun 2015	Sep 2015
AFP (ULN < 5.5 IU/mL)	86	120	153	167	16	3	2	3	2	1.5	1.2

ULN: Upper limit of normal; AFP: Alpha fetoprotein.

Table 4 Laboratory findings during treatment (case 2)

	Baseline	Week 1	Week 2	Week 4	Week 6	Week 12 (ETR)	Week 12 post therapy (SVR-12)	Week 24 post therapy (SVR-24)
Hgb (g/L)	132	130	115	99	104	103	131	125
WBC (G/L)	5.7	6.4	8.8	5.1	4.5	6.2	6.7	8.1
PLT (G/L)	183	166	304	320	278	308	168	182
Tbil/Dbil (μmol/L)	7/3.6	19/13	24/13	16/10	9/4	34/23	5.2/2.3	6.4/2.6
ALT (U/L)	99	61	53	265	510	45	14	16
PT (s)	13.5	13.7	13.1	15.6	16.3	13.4	14.7	14.4
Alb (g/L)	42	40	49	45	42	43	47	47
HCV RNA (IU/mL)	1799000		UND	UND		UND	UND	UND
FIBROMAXTM	A3/F4					A3/F4
TBA (μmol/L)	4.5					19	5.2