Relationship of serum polyunsaturated fatty acids with cytokines in colorectal cancer

doi:10.3748/wjg.v22.i8.2524

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World Journal of Gastroenterology

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World J Gastroenterol. Feb 28, 2016; 22(8): 2524-2532
Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2524

Table 1 Multivariate analysis of the relationship between n-6 polyunsaturated fatty acid and cytokines

	C18:2 n-6 (quartiles),%¹					C18:3 n-6 (quartiles),%¹					C20:3 n-6 (quartiles),%¹
Quartiles limits	< 22.74	22.74-24.46	24.46-26.50	> 26.50	P value for trend	< 0.21	0.21-0.28	0.28-0.34	> 0.34	P value for trend	< 1.28	1.28-1.59	1.59-1.92	> 1.92	P value for trend
Median	21.55	23.75	25.47	28.54	P value for trend	0.17	0.24	0.31	0.40		1.05	1.38	1.72	2.13	P value for trend
IFN-γ (pg/mL)	0.55	0.22	0.81	0.33	0.834	0.41	0.27	0.40	0.46	0.943	0.30	0.46	0.34	0.41	0.760
IL-10 (pg/mL)	2.63	2.06	2.70	1.98	0.959	2.19	2.27	1.99	2.68	0.828	2.04	2.10	2.50	2.63	0.552
IL-8 (pg/mL)	66.00	48.43	51.01	30.76	0.259	57.55	21.77	45.19	73.44	0.436	62.18	34.07	47.60	64.69	0.266
TNF-α (pg/mL)	7.36	7.34	9.23	6.68	0.443	9.74	6.69	7.32	8.30	0.450	7.76	6.97	8.29	8.43	0.743
MMP-2 (ng/mL)	12.26	12.86	10.89	8.80	0.485	13.54	9.68	7.54	12.24	0.488	10.79	11.57	12.86	11.62	0.863
MMP-7 (ng/mL)	2.96	3.10	2.94	3.06	0.735	3.39	2.55	3.22	3.00	0.426	3.01	3.10	2.62	3.14	0.444
MMP-9 (ng/mL)	12.03	12.16	10.75	10.71	0.058	10.86	9.89	12.14	12.57	0.255	10.61	9.81	14.03	11.83	0.187
	C20:4 n-6 (quartiles),%¹					C22:5 n-6 (quartiles),%¹					PUFA n-6 (quartiles),%¹
Quartiles limits	< 6.72	6.72-7.75	7.75-9.01	> 9.01	P value for trend	< 0.13	0.13-0.18	0.18-0.25	> 0.25	P value for trend	< 32.52	32.52-34.53	34.53-36.58	36.58	P value for trend
edian	5.99	7.29	8.19	9.74	P value for trend	0.06	0.15	0.21	0.31		31.07	33.65	35.56	37.92	P value for trend
IFN-γ (pg/mL)	0.41	0.46	0.22	0.41	0.298	0.52	0.22	0.27	0.41	0.709	0.30	0.67	0.41	0.27	0.610
IL-10 (pg/mL)	2.14	2.97	1.85	2.63	0.681	2.20	1.74	2.68	2.57	0.453	2.23	2.77	2.00	2.01	0.287
IL-8 (pg/mL)	41.89	44.92	41.14	65.83	0.129	46.68	30.06	66.74	62.79	0.348	47.90	41.00	78.72	43.19	0.983
TNF-α (pg/mL)	6.45	7.78	7.39	9.38	0.182	7.32	6.67	8.41	7.43	0.457	7.17	6.83	9.38	8.61	0.480
MMP-2 (ng/mL)	12.39	11.16	8.45	13.54	0.741	9.75	6.28	14.83	13.41	0.223	10.60	12.19	13.41	8.88	0.065
MMP-7 (ng/mL)	3.02	3.04	2.94	3.52	0.055	3.10	2.80	2.87	3.55	0.981	3.04	2.91	3.20	3.03	0.870
MMP-9 (ng/mL)	10.94	10.93	11.96	11.81	0.200	10.91	9.97	13.00	11.01	0.493	10.32	12.40	12.56	10.89	0.868

¹The association of n-6 PUFA and cytokines were adjusted for potential confounding factors, including age, sex, smoke, alcohol drinking, body mass index, total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol, triglycerides, total energy, protein, fat and carbohydrate intake. PUFA: Polyunsaturated fatty acids; IFN-γ: Interferon gamma; IL-10: Interleukin-10; TNF-α: Tumor necrosis factor-α; MMP-2: Matrix metalloproteinase-2.

Table 2 Multivariate analysis of the relationship between n-3 polyunsaturated fatty acid and cytokines

	C18:3 n-3 (quartiles),%¹					C20:5 n-3 (quartiles),%¹						C22:5 n-3 (quartiles),%¹
Quartiles limits	< 0.33	0.33-0.47	0.47-0.61	> 0.61	P value for trend	< 0.20	0.20-0.31	0.31-0.46	> 0.46	P value for trend	Quartiles limits	< 0.32	0.32-0.40	0.40-0.49	> 0.49	P value for trend
Median	0.26	0.41	0.53	0.74	P value for trend	0.15	0.25	0.37	0.60	P value for trend	Median	0.27	0.36	0.44	0.59	P value for trend
IL-10 (pg/mL)	2.58	2.34	1.93	2.42	0.465	2.38	1.96	2.54	2.46	0.959	IL-10	2.47	2.66	2.06	2.00	0.478
IL-6 (pg/mL)	1.75	1.43	1.34	1.90	0.184	1.45	1.89	1.74	2.09	0.810	IL-6	1.55	1.71	1.79	1.94	0.088
TNF-α (pg/mL)	7.35	7.78	8.36	7.43	0.644	7.45	8.59	7.43	6.92	0.821	TNF-α	7.27	8.71	6.73	7.43	0.373
MMP-7 (ng/mL)	3.02	2.97	2.87	3.27	0.520	2.62	3.10	3.10	3.14	0.412	MMP-7	2.66	3.08	3.00	3.14	0.323
	C22:6 n-3 (quartiles),%¹					PUFA n-3¹
Quartiles limits	< 1.56	1.56-2.13	2.13-2.62	> 2.62	P value for trend	< 2.79	2.79-3.30	3.30-4.08	> 4.08	P value for trend
Median	1.31	1.79	2.36	3.01	P value for trend	2.45	3.04	3.73	4.45	P value for trend
IL-10 (pg/mL)	2.63	2.64	1.93	2.30	0.838	2.63	2.25	1.98	2.34	0.074
IL-6 (pg/mL)	1.79	1.87	1.43	1.34	0.679	1.85	1.51	1.25	1.83	0.279
TNF-α (pg/mL)	7.03	7.66	7.07	8.40	0.636	7.27	7.08	9.49	7.21	0.728
MMP-7 (ng/mL)	2.94	3.13	3.26	2.97	0.827	2.92	2.69	3.61	3.20	0.160

Table 3 Multivariate analysis of the relationship between n-6, n-3 polyunsaturated fatty acid indicators and cytokines

	n-6 PUFA/n-3 PUFA¹					C20:4 n-6/(C20:5 n-3 + C22:6 n-3)¹
Quartiles limits	< 8.47	8.47-10.25	10.25-12.66	> 12.66	P value for trend	< 2.64	2.64-3.21	3.21-3.94	> 3.94	P value for trend
Median	7.49	9.41	11.64	14.08	P value for trend	2.16	2.95	3.56	4.79	P value for trend
IFN-γ (pg/mL)	0.45	0.46	0.30	0.41	0.240	0.27	0.55	0.55	0.30	0.157
IL-8 (pg/mL)	23.82	70.90	48.43	50.67	0.495	18.58	53.84	63.53	60.30	0.413
TNF-α (pg/mL)	7.01	10.53	6.62	7.45	0.600	6.81	9.20	7.98	7.36	0.094
MMP-2 (ng/mL)	5.80	14.95	11.55	11.37	0.549	4.12	11.48	14.13	11.37	0.980
MMP-9 (ng/mL)	9.88	11.81	11.27	12.24	0.734	9.73	10.30	12.56	12.26	0.495
	C20:4 n-6/C20:5 n-3¹					C20:4 n-6/(n-6 PUFA + n-3 PUFA)¹
Quartiles limits	< 16.65	16.65-25.18	25.18-39.20	> 39.20	P value for trend	< 0.18	0.18-0.21	0.21-0.23	> 0.23	P value for trend
edian	12.66	19.67	30.67	48.51	P value for trend	0.16	0.20	0.22	0.25	P value for trend
IFN-γ(pg/mL)	0.29	0.46	0.46	0.30	0.906	0.41	0.27	0.55	0.46	0.769
IL-8 (pg/mL)	26.78	41.71	80.35	50.88	0.978	23.13	43.41	71.56	65.01	0.108
TNF-α (pg/mL)	6.63	8.01	8.47	8.30	0.334	6.29	8.15	8.70	8.40	0.432
MMP-2 (ng/mL)	8.99	10.84	12.81	13.77	0.977	9.10	11.35	12.24	12.81	0.200
MMP-9 (ng/mL)	9.73	11.32	12.59	12.14	0.058	10.85	10.52	12.57	11.90	0.350

¹The association of n-6 PUFA and cytokines were adjusted for potential confounding factors, including age, sex, smoke, alcohol drinking, body mass index, total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol, triglycerides, total energy, protein, fat and carbohydrate intake. PUFA: Polyunsaturated fatty acids; IFN-γ: Interferon gamma; IL-8: Interleukin-8; TNF-α: Tumor necrosis factor-α; MMP-2: Matrix metalloproteinase-2.

Citation: Jia HJ, Zhang PJ, Liu YL, Jiang CG, Zhu X, Tian YP. Relationship of serum polyunsaturated fatty acids with cytokines in colorectal cancer. World J Gastroenterol 2016; 22(8): 2524-2532
URL: https://www.wjgnet.com/1007-9327/full/v22/i8/2524.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i8.2524