Case Report
Copyright ©The Author(s) 2016.
World J Gastroenterol. Dec 21, 2016; 22(47): 10465-10470
Published online Dec 21, 2016. doi: 10.3748/wjg.v22.i47.10465
Table 1 Results of our patient
A: laboratory findings
B: immunophenotyping of liver and bone marrow biopsy
Analysis (Unit)ResultsReference valueImmunophenotypeResultsTypical HSTCL[1,3]
White blood cell count (× 109/L)4.64.0-10.0CD 2 and 3++
Platelet count (× 109/L)42150-400CD 4 and 5--
Hemoglobin (mmol/L)7.78.5-11.0CD 7++/-
Bilirubin (μmol/L)1750-17CD 8+/--
ALP (IU/L)2650-125CD 16-+/-
GGT (IU/L)1540-45CD 56++
ASAT (IU/L)2500-34γδ-T-cell receptor++
ALAT (IU/L)4370-44TIA-+
LDH (IU/L)7010-247
Table 2 Number of Crohn’s disease cases with hepatosplenic T-cell lymphoma[7,15]
AgeCombination therapyMonotherapyTotal
> 35 year707
< 35 year201131
Table 3 Cases of γδ-hepatosplenic T-cell lymphoma in patients with Crohn’s disease on thiopurine monotherapy
IndexAge, sexYears of thiopurinePresentationTreatmentSurvival (mo)
treatment (type)
Index case47, M14 (AZT)HSM, icterus, anemia, thrombocytopeniaCh. (CHOP)< 1
Selvaraj et al[7] 2013 (AERS 6751796)18, M< 1 (AZT, 6MP)NSNS7
Selvaraj et al[7] 2013 (AERS 7554658)13, MNS (6MP)NSNSNS
Fowler et al[18] 201019, M6 (AZT)SM, leucocytopeniaCh. (NS) + splenectomy4
Fowler et al[18] 201022, M8 (6MP)SM, night sweats, fever, abdominal tendernessCh. (NS)Survival
Ochenrider et al[8] 201018, M5 (6MP)Fever, night sweats, SM, anemia, thrombocytopeniaCh. (Pentostatin, ICE) + auto-SCT7
Humphreys et al[19] 200827, F5 (AZT)Fever, nights sweats, pancytopenia, HSMInterferon-α> 31
Zeidan et al[20] 200731, M6 (6MP)1Chills, SM, fever, pancytopeniaCh. (CHOP, cytarabine, ESHAP)7
Falchook et al[15] 2006NSNS (6MP)SMCh. (NS)NS
Mittal et al[21] 200618, M6 (AZT)Fever, pancytopenia, HSMCh. (IVE, ESHAP, alemtuzumabNS
fludarabine) + allo-SCT
Navarro et al[22] 200335, M5.6 (AZT)Fever, night sweats, HSM, anemia, thrombocytopeniaCh. (NS) + splenectomyNS
Lémann et al[23] 1998NS4 (AZT)NSNSNS