Case Report
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 21, 2016; 22(47): 10465-10470
Published online Dec 21, 2016. doi: 10.3748/wjg.v22.i47.10465
Hepatosplenic T-cell lymphoma in a 47-year-old Crohn’s disease patient on thiopurine monotherapy
Maartje M van de Meeberg, Lauranne A A P Derikx, Harm A M Sinnige, Peet Nooijen, D Lucette Schipper, Loes H C Nissen
Maartje M van de Meeberg, D Lucette Schipper, Lauranne AAP Derikx, Loes HC Nissen, Department of Gastroenterology and Hepatology, Jeroen Bosch Hospital, 5200 ME ’s-Hertogenbosch, The Netherlands
Harm AM Sinnige, Department of Hematology, Jeroen Bosch Hospital, 5200 ME ’s-Hertogenbosch, The Netherlands
Peet Nooijen, Department of Pathology, Jeroen Bosch Hospital, 5200 ME ’s-Hertogenbosch, The Netherlands
Author contributions: van de Meeberg MM is first author and composed the manuscript; Derikx LAAP and Nissen LHC contributed equally in writing the manuscript; Sinnige HAM, Nooijen P and Schipper DL revised the manuscript; Schipper DL also provided the case.
Institutional review board statement: This case report was exempt.
Informed consent statement: The patient gave verbal informed consent prior to composing the manuscript.
Conflict-of-interest statement: All the authors have no conflicts of interests to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Maartje M van de Meeberg, MD, Department of Gastroenterology and Hepatology, Jeroen Bosch Hospital, Henri Dunantstraat 1, 5200 ME ’s-Hertogenbosch, The Netherlands.
Telephone: +31-73-5532000 Fax: +31-73-5538804
Received: June 26, 2016
Peer-review started: June 28, 2016
First decision: August 8, 2016
Revised: September 1, 2016
Accepted: September 28, 2016
Article in press: September 28, 2016
Published online: December 21, 2016
Core Tip

Core tip: In this manuscript we provide an overview of all known cases in literature with Crohn’s disease (CD) who developed hepatosplenic T-cell lymphoma (HSTCL) while on thiopurine monotherapy. In addition, we present our case of a patient with CD on thiopurine monotherapy who developed HSTCL at a relatively old age. This emphasizes that HSTCL may develop at all ages, even when the patient is solely on thiopurine monotherapy.