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©The Author(s) 2016.
World J Gastroenterol. Oct 28, 2016; 22(40): 8949-8955
Published online Oct 28, 2016. doi: 10.3748/wjg.v22.i40.8949
Published online Oct 28, 2016. doi: 10.3748/wjg.v22.i40.8949
Table 1 Computed tomography parameters
CT scanner | 4-slice MDCT | 64- or 256- or 320- slice MDCT | ||||||
No. of patients | 4 | 2 | 5 | 5 | 2 | 10 | 4 | 6 |
Contrast material (mgI/mL) | 370 | 300 | 370 | 370 | 370 | 370 | 300 | 370 |
Contrast material dose | 100 mL | 100 mL | 600 mgI/kg | 100 mL | 100 mL | 600 mgI/kg | 100 mL | 600 mgI/kg |
Injection rate | 2.5 mL/s | 2.5 mL/s | 20 s1 | 3 mL/s | 2.5 mL/s | 30 s1 | 2.5 mL/s | 20 s1 |
Portal phase delay (s) | 70 | 70 | 55 | 70 | 70 | 60 | 60 | 70 |
Tube voltage (kVp) | 120 | 120 | 120 | 120 | 120 | 120 | 120 | 120 |
Tube current (mAs) | 300 | 300 | 300 | Auto | Auto | Auto | Auto | Auto |
Reconstruction thickenss (mm) | 5 | 3 | 3 | 5 | 3 | 1 | 5 | 2 |
Table 2 Correlation between liver volume and fibrosis stage
Parameter | F0 (n = 11) | F1 (n = 5) | F2 (n = 1) | F3 (n = 9) | F4 (n = 12) | r | P value |
Total volume (cm3) | 1252.3 ± 155.1 | 1280.4 ± 240.0 | 1235.8 | 1364.5 ± 320.0 | 1030.2 ± 366.1 | -0.193 | NS |
LLS (%) | 18.3 ± 1.9 | 22.1 ± 3.9 | 21.5 | 25.3 ± 8.8 | 26.5 ± 8.8 | 0.465 | 0.003 |
LMS (%) | 12.6 ± 1.7 | 12.0 ± 3.7 | 16.2 | 11.3 ± 2.8 | 11.1 ± 3.5 | -0.248 | NS |
Caudate lobe (%) | 3.0 ± 1.2 | 3.7 ± 0.8 | 3.2 | 5.3 ± 1.0 | 9.3 ± 4.1 | 0.815 | < 0.001 |
RL (%) | 66.1 ± 2.2 | 62.1 ± 5.6 | 59.1 | 58.0 ± 10.4 | 52.7 ± 10.5 | -0.563 | < 0.001 |
Table 3 Receiver operating characteristic analysis of the diagnostic performance of volume percentage of caudate lobe for hepatic fibrosis
F0 vs ≥ F1 | ≤ F1 vs ≥ F2 | ≤ F2 vs ≥ F3 | ≤ F3 vs F4 | |
Az value | 0.896 | 0.929 | 0.955 | 0.923 |
Cutoff value | 3.957 | 4.789 | 4.789 | 5.834 |
Sensitivity (%) | 88.9 | 81.8 | 85.7 | 83.3 |
Specificity (%) | 90.9 | 93.8 | 94.1 | 88.4 |
Accuracy (%) | 89.4 | 86.8 | 89.4 | 86.8 |
PPV (%) | 96.0 | 94.7 | 94.7 | 76.9 |
NPV (%) | 76.9 | 78.9 | 84.2 | 92.0 |
- Citation: Fujita N, Nishie A, Asayama Y, Ishigami K, Ushijima Y, Takayama Y, Okamoto D, Shirabe K, Yoshizumi T, Kotoh K, Furusyo N, Hida T, Oda Y, Fujioka T, Honda H. Fibrosis in nonalcoholic fatty liver disease: Noninvasive assessment using computed tomography volumetry. World J Gastroenterol 2016; 22(40): 8949-8955
- URL: https://www.wjgnet.com/1007-9327/full/v22/i40/8949.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i40.8949