Fibrosis in nonalcoholic fatty liver disease: Noninvasive assessment using computed tomography volumetry

doi:10.3748/wjg.v22.i40.8949

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Gastroenterol. Oct 28, 2016; 22(40): 8949-8955
Published online Oct 28, 2016. doi: 10.3748/wjg.v22.i40.8949

Fibrosis in nonalcoholic fatty liver disease: Noninvasive assessment using computed tomography volumetry

Nobuhiro Fujita, Akihiro Nishie, Yoshiki Asayama, Kousei Ishigami, Yasuhiro Ushijima, Yukihisa Takayama, Daisuke Okamoto, Ken Shirabe, Tomoharu Yoshizumi, Kazuhiro Kotoh, Norihiro Furusyo, Tomoyuki Hida, Yoshinao Oda, Taisuke Fujioka, Hiroshi Honda

Nobuhiro Fujita, Akihiro Nishie, Kousei Ishigami, Yasuhiro Ushijima, Daisuke Okamoto, Hiroshi Honda, Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan

Yoshiki Asayama, Department of Advanced Imaging and Interventional Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan

Yukihisa Takayama, Department of Radiology Informatics and Network, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan

Ken Shirabe, Tomoharu Yoshizumi, Department of Surgery and Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan

Kazuhiro Kotoh, Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan

Norihiro Furusyo, Department of General Internal Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan

Tomoyuki Hida, Yoshinao Oda, Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan

Taisuke Fujioka, CT Application, Philips Electronics Japan Medical Systems, Minato-ku, Tokyo 108-8507, Japan

Author contributions: Fujita N and Nishie A designed and performed the research and wrote the paper; Asayama Y, Ishigami K, Ushijima Y, Takayama Y, Okamoto D, Shirabe K, Yoshizumi T, Kotoh K and Furusyo N provided clinical advice; Hida T and Oda Y provided pathological advice; Fujioka T provided technical advice; Honda H supervised the report.

Supported by a Grant-in-in-Aid for Scientific Research (C) (No. 26461796) from the Japanese Ministry of Education, Culture, Sports, Science, and Technology.

Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Kyushu University.

Informed consent statement: The requirements for informed consent were waived due to the retrospective design. The details of the study are published on the home page of Kyushu University.

Conflict-of-interest statement: One author (Fujioka T) is an employee of Philips Electronics Japan.

Data sharing statement: No additional data are available.

Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

Correspondence to: Akihiro Nishie, MD, PhD, Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. anishie@radiol.med.kyushu-u.ac.jp

Telephone: +81-92-6425695 Fax: +81-92-6425708

Received: June 24, 2016
Peer-review started: June 28, 2016
First decision: August 22, 2016
Revised: September 2, 2016
Accepted: September 28, 2016
Article in press: September 28, 2016
Published online: October 28, 2016
Processing time: 124 Days and 2.7 Hours

Core Tip

Core tip: This is a retrospective study to elucidate the morphological change in nonalcoholic fatty liver disease (NAFLD) using computed tomography (CT) volumetry and to evaluate the diagnostic performance of CT volumetry for discriminating the fibrosis stage in NAFLD. The volume percentages of the caudate lobe calculated by CT volumetry were significantly increased with the increase in fibrosis stage in NAFLD. The volume percentage of the caudate lobe is a useful diagnostic parameter for staging fibrosis in patients with NAFLD. The evaluation of liver volume using CT volumetry is useful for predicting the fibrosis stage in NAFLD.