Role and mechanisms of action of Escherichia coli Nissle 1917 in the maintenance of remission in ulcerative colitis patients: An update

Table 1 Main results from trials on Escherichia coli Nissle on ulcerative colitis

Efficacy of EcN 1917 in maintanance of UC remission
Results from major randomized controlled clinical trials
EcN 200 mg/d is equivalent to Mesalazine 1000 mg/d in mantainance of UC remission[27]
EcN 400 mg/d is equivalent to to Mesalazine 2400 mg/d in maintanance of UC remission following an acute flare[28]
EcN 200 mg/d is equivalent to Mesalazine 1500 mg/d in mantainance of UC remission[10]
Results from minor studies
Rectal admistration of EcN 40 mL/d is effective in moderate distal active UC[30]
EcN 200 mg/d is equivalent to Mesalazine 1500 mg/d in maintanance of UC remission[6]

EcN: Escherichia coli Nissle; UC: Ulcerative colitis.

Table 2 Main potential clinical indications for Escherichia coli Nissle in gastroenterology

Maintenance of remission in ulcerative colitis[6,10,27,28]

Irritable bowel syndrome[34-37]

Constipation[38,39]

Acute diarrhea[6,40]

Collagenous colitis[41]

Uncomplicated diverticular disease[7]