Copyright
©The Author(s) 2016.
World J Gastroenterol. Jun 21, 2016; 22(23): 5301-5316
Published online Jun 21, 2016. doi: 10.3748/wjg.v22.i23.5301
Published online Jun 21, 2016. doi: 10.3748/wjg.v22.i23.5301
Table 1 Pathological changes in various mice after azoxymethane/dextran sulfate sodium treatment
| Ingested DSS concentration | Body weight loss(> 20%) | Granulocyte infiltration (> 400/field) | Fibroblast accumulation (> 20% type I collagen+ areas) | Tumor numbers | |
| Wild-type mice | 3.0% | + | + | + | > 20 |
| CCR1-deficient mice | 3.0% | - | - | - | < 5 |
| 4.5% | + | + | + | > 20 | |
| CCR5-deficient mice | 3.0% | - | - | - | < 5 |
| 4.5% | + | + | - | < 7 | |
| CCL3-deficient mice | 3.0% | - | - | - | < 5 |
| 4.5% | + | + | - | < 5 |
- Citation: Mukaida N, Sasaki S. Fibroblasts, an inconspicuous but essential player in colon cancer development and progression. World J Gastroenterol 2016; 22(23): 5301-5316
- URL: https://www.wjgnet.com/1007-9327/full/v22/i23/5301.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i23.5301