Transarterial administration of integrin inhibitor loaded nanoparticles combined with transarterial chemoembolization for treating hepatocellular carcinoma in a rat model

Table 1 Immunohistochemical expression of matrix metalloprotein 9 and vascular endothelial growth factor in hepatocellular carcinoma (%) in groups A and B

	Group	TACE + GRGDSP						TACE + GRGDSP loaded nanoparticles						P value
	Score	0	1	2	3	4	5	0	1	2	3	4	5
VEGF	Tumor	3	13	28	20	20	16	29	5	18	20	18	10	0.000
MMP-9	Tumor	0	1	17	18	42	22	0	6	36	41	12	5	0.000

MMP-9: Matrix metalloprotein 9; VEGF: Vascular endothelial growth factor; TACE: Transarterial chemoembolization.

Table 2 Immunohistochemical expression of matrix metalloprotein 9 and vascular endothelial growth factor in hepatocellular carcinoma (%) in groups A and C

	Group	TACE						TACE + GRGDSP loaded nanoparticles						P value
	Score	0	1	2	3	4	5	0	1	2	3	4	5
VEGF	Tumor	0	2	10	11	16	61	29	5	18	20	18	10	0.000
MMP-9	Tumor	0	6	4	0	9	81	0	6	36	41	12	5	0.000

MMP-9: Matrix metalloprotein 9; VEGF: Vascular endothelial growth factor; TACE: Transarterial chemoembolization.