Copyright
©The Author(s) 2016.
World J Gastroenterol. May 28, 2016; 22(20): 4802-4811
Published online May 28, 2016. doi: 10.3748/wjg.v22.i20.4802
Published online May 28, 2016. doi: 10.3748/wjg.v22.i20.4802
Table 1 Case reports about the association Crohn’s disease-hydradenitis suppurativa
Ref. | n | Localization of CD | Localization of HS | CD predates HS |
Ostlere et al[11], 1991 | 3 | Colon | Anogenital | NR |
Burrows et al[12], 1992 | 2 | Colon | Anogenital, axillae, groin | NR |
Gower-Rousseau et al[13], 1992 | 1 | Ileo-colon | Perineum | NR |
Attanoos et al[14], 1993 | 3 | Colon, ileo-colon, colon-jejunum | Anogenital, axillae, perineum | Yes |
Tsianos et al[15], 1995 | 1 | Colon | Anogenital, axillae, sternum | Yes |
Roy et al[16], 1997 | 1 | Ileo-colon | Axillae | NR |
Martínez et al[17], 2001 | 1 | Ileo-colon | Axillae | Yes |
Roussomoustakaki et al[18], 2003 | 1 | Ileo-colon | Anogenital, axillae, groin | No |
Yazdanyar et al[19], 2010 | 2 | Colon | Axillae, groin, submammary | No |
Goertz et al[20], 2008 | 1 | Colon | Perianal | Yes |
dos Santos et al[21], 2012 | 1 | Rectum | Perianal | Yes |
Hiraiwa et al[22], 2013 | 1 | Ulcerative colitis | Groin | Yes |
Table 2 Main clinical and pathogenesis features of hydradenitis suppurativa and inflammatory bowel disease (adapted from van der Zee et al[23])
CD | UC | HS | |
Localization | Entire alimentary tract | Colon | Inverse areas of the skin |
Layer of inflammation | Transmural | Mucosa | Deep derm |
Confluency of lesions | No (skip lesions) | Yes | Yes |
Fistulae | Yes | No | Yes |
Influence of smoking | Aggravates | No (or improvement) | Aggravates |
Disease chronicity | Yes | Yes | Yes |
Genetic predisposition | Yes | Yes | Yes |
Influence of microbiota | Yes | Yes | Yes |
Female predominance | ↑ | ↑ | ↑↑ |
Response to anti-TNFα therapy | Yes | Yes | Yes |
- Citation: Principi M, Cassano N, Contaldo A, Iannone A, Losurdo G, Barone M, Mastrolonardo M, Vena GA, Ierardi E, Di Leo A. Hydradenitis suppurativa and inflammatory bowel disease: An unusual, but existing association. World J Gastroenterol 2016; 22(20): 4802-4811
- URL: https://www.wjgnet.com/1007-9327/full/v22/i20/4802.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i20.4802