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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 28, 2016; 22(20): 4802-4811
Published online May 28, 2016. doi: 10.3748/wjg.v22.i20.4802
Published online May 28, 2016. doi: 10.3748/wjg.v22.i20.4802
Hydradenitis suppurativa and inflammatory bowel disease: An unusual, but existing association
Mariabeatrice Principi, Antonella Contaldo, Andrea Iannone, Giuseppe Losurdo, Michele Barone, Enzo Ierardi, Alfredo Di Leo, Gastroenterology Section, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy
Nicoletta Cassano, Gino Antonio Vena, Dermatology and Venereology Private Practice, 70124 Bari/76121 Barletta, Italy
Mario Mastrolonardo, Dermatology Unit, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy
Author contributions: Principi M, Ierardi E and Di Leo A designed the study, revised the manuscript and approved the final version; Cassano N, Contaldo A, Iannone A, Losurdo G and Mastrolonardo M collected the data and wrote the manuscript; Barone M and Vena GA revised the final version before approval.
Conflict-of-interest statement: No conflict of interest is declared by authors.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Enzo Ierardi, Professor, Gastroenterology Section, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy. ierardi.enzo@gmail.com
Telephone: +39-80-5594034 Fax: +39-80-5593088
Received: March 18, 2016
Peer-review started: March 21, 2016
First decision: March 31, 2016
Revised: April 11, 2016
Accepted: May 4, 2016
Article in press: May 4, 2016
Published online: May 28, 2016
Processing time: 61 Days and 20.4 Hours
Peer-review started: March 21, 2016
First decision: March 31, 2016
Revised: April 11, 2016
Accepted: May 4, 2016
Article in press: May 4, 2016
Published online: May 28, 2016
Processing time: 61 Days and 20.4 Hours
Core Tip
Core tip: The present topic outlines the main data regarding a possible association between hydradenitis suppurativa and inflammatory bowel disease with particular attention to epidemiology, etiopathogenetic factors, genetic susceptibility, intestinal/skin microbiota and therapeutic analogies. Finally, an unregulated inflammation leading to microscopic granulomatous wounds may cause the lesions typical of both diseases, particularly when they coexist. However, this is still a largely unexplored field, and further studies are required.