Plasma long noncoding RNA expression profile identified by microarray in patients with Crohn’s disease

Table 1 Clinical characteristics and laboratory tests of enrolled subjects

	CD (n = 12)	Control (n = 12)	P value
Gender (M/F)	6/6	7/5	> 0.0501
Age (yr)	37.8 ± 14.6	42.8 ± 14.8	0.420
BMI (kg/m2)	20.8 ± 1.8	23.3 ± 1.4	0.001
CRP (mg/L)	47.3 ± 6.9	4.4 ± 2.1	< 0.001
WBC (10E9/L)	11.6 ± 1.6	5.7 ± 0.9	< 0.001

¹χ² = 0.17.

Table 2 Top 10 dysregulated long noncoding RNAs and mRNAs in Chrohn’s disease patients

Gene name	Transcript	Fold change
Up-regulated lncRNAs
GUSBP2	ENST00000466668	626.49
RP5-968D22.1	ENST00000422548	444.43
RP11-68L1.2	ENST00000502712	324.23
RP11-428F8.2	ENST00000425364	245.98
GAS5-AS1	NR_037605	236.81
RP11-923I11.5	ENST00000562996	196.25
DDX11-AS1	NR_038927	192.07
XLOC_005955	TCONS_00014043	175.81
XLOC_005807	TCONS_00012771	87.76
AC009133.20	ENST00000569039	82.92
Down-regulated lncRNAs
AF113016	uc001ody.3	481.03
ALOX12P2	ENST00000575787	298.81
AGSK1	uc010bmo.1	208.70
CTC-338M12.3	ENST00000509252	172.74
AC064871.3	ENST00000413954	96.13
RP11-510H23.3	ENST00000431104	77.63
LOC729678	uc011dhd.2	69.95
XLOC_010037	TCONS_00020749	66.82
LOC283761	NR_027074	58.70
XLOC_013142	TCONS_00027621	45.60
Up-regulated mRNAs
TBC1D17	NM_024682	488.98
GALNT8	NM_017417	303.23
DENND1A	NM_024820	301.75
VANGL1	NM_001172411	247.83
VPS29	NM_057180	189.17
EHD1	NM_006795	132.08
FAM84A	NM_145175	121.69
SAA4	NM_006512	105.50
ZNF33A	NM_006974	101.84
GKN1	NM_019617	91.51
Down-regulated mRNAs
CCL3L3	NM_001001437	994.63
BGLAP	NM_199173	501.53
SLC51B	NM_178859	499.44
BAG4	NM_004874	134.54
MAU2	NM_015329	115.54
TSNARE1	NM_145003	106.10
DIXDC1	NM_033425	93.11
ZBTB25	NM_006977	82.42
CMTM8	NM_178868	75.71
ANXA1	NM_000700	69.07

The top 10 dysregulated lncRNAs and mRNAs are listed based on significantly differentially expressed lncRNAs and mRNAs (P < 0.05) and the fold change.