Shear wave elastography results correlate with liver fibrosis histology and liver function reserve

Table 1 Liver biochemistry assays (median ± IQR) by fibrosis grade (n = 14)

Variable	F0 control	F2	F3	F4	P value
	(n = 2)	(n = 3)	(n = 7)	(n = 2)
Albumin (g/Dl)	3.9 ± 1.81	3.1 ± 0.51	2.6 ± 0.91,2	1.8 ± 0.52	0.021
Total protein (g/dL)	6.5 ± 1.1	7.0 ± 1.7	6.1 ± 1.2	6.2 ± 1.8	0.639
AST (IU/L)	28 ± 14	21 ± 12	28 ± 15	60 ± 76	0.711
ALT (IU/L)	44 ± 17	43 ± 22	31 ± 28	58 ± 27	0.669
GGT (IU/L)	5.2 ± 2.1	5 ± 1.3	5.2 ± 2.6	6.3 ± 6.2	0.938
ALP (IU/L)	44 ± 25	49 ± 8	61 ± 19	74 ± 31	0.140
TBil (mg/dL)	0.27 ± 0.08	0.24 ± 0.07	0.25 ± 0.11	0.33 ± 0.21	0.865
UBil (mg/dL)	0.13 ± 0.05	0.13 ± 0.06	0.16 ± 0.10	0.17 ± 0.12	0.825
CBil (mg/dL)	0.15 ± 0.03	0.09 ± 0.05	0.10 ± 0.07	0.16 ± 0.09	0.318

^1,2The two groups with no common letter have a statistically significant difference. ALP: Alkaline phosphatase; ALT: Alanine aminotransferase; AST: Asparate aminotransferase; CBil: Conjugated bilirubin; GGT: Gamma-glutamyl transpeptadase; IQR: Interquartile range; TBil: Total bilirubin; UBil: Unconjugated bilirubin.

Table 2 Shear wave elastography elastic modulus (kPa, median ± IQR) by fibrosis grade (n = 14)

Variable	F0 control	F2	F3	F4	P value
	(n = 2)	(n = 3)	(n = 7)	(n = 2)
LSM	5.0 ± 0.41	6.5 ± 5.41,2	14.6 ± 9.42,3	28.3 ± 17.84	0.004

^1,2,3,4The two groups with no common letter have a statistically significant difference. IQR: Interquartile range; LSM: Liver stiffness modulus.

Table 3 Pharmacokinetics (median ± IQR) of plasma monoethylglycinexylidide (n = 14)

Variable	F0 control	F2	F3	F4	P value
	(n = 2)	(n = 3)	(n = 7)	(n = 2)
C10 min (ng/mL)	252 ± 31	197 ± 381	99 ± 105	72 ± 38	0.280
C30 min (ng/mL)	327 ± 561	268 ± 3751,2	120 ± 312,3	73 ± 203,4	0.033
C60 min (ng/mL)	274 ± 711	258 ± 3361,2	93 ± 262,3	51 ± 373,4	0.020
Cmax (ng/mL)	327 ± 56	282 ± 332	143 ± 106	82 ± 22	0.069
tmax (min)	30.0 ± 0.0	40.0 ± 20.0	30.0 ± 20.0	17.5 ± 5.0	0.120
t½max (min)	141.3 ± 110.1	151.1 ± 188.3	46.9 ± 50.2	74.9 ± 75.9	0.545
AUC (ng/mL·min)	16644 ± 31391	14421 ± 25151,2	6100 ± 22862,3	3970 ± 16703,4	0.016
Kmax (ng/mL/min)	43.7 ± 7.2	38.1 ± 83.8	17.7 ± 22.8	6.6 ± 1.5	0.358

^1,2,3,4The two groups with no common letter have a statistically significant difference. C_{10 min}, C_{30 min} and C_{60 min}: Concentrations at 10, 30, and 60 min, respectively; C_max: The maximum concentration; IQR: Interquartile range; K_max: The maximum concentration increase per unit time; t_max and t_½max: Times to the maximum and ½ of the maximum concentration; AUC: Area under the curve.