Basic Study
Copyright ©The Author(s) 2016.
World J Gastroenterol. May 7, 2016; 22(17): 4338-4344
Published online May 7, 2016. doi: 10.3748/wjg.v22.i17.4338
Table 1 Liver biochemistry assays (median ± IQR) by fibrosis grade (n = 14)
VariableF0 controlF2F3F4P value
(n = 2)(n = 3)(n = 7)(n = 2)
Albumin (g/Dl)3.9 ± 1.813.1 ± 0.512.6 ± 0.91,21.8 ± 0.520.021
Total protein (g/dL)6.5 ± 1.17.0 ± 1.76.1 ± 1.26.2 ± 1.80.639
AST (IU/L)28 ± 1421 ± 1228 ± 1560 ± 760.711
ALT (IU/L)44 ± 1743 ± 2231 ± 2858 ± 270.669
GGT (IU/L)5.2 ± 2.15 ± 1.35.2 ± 2.66.3 ± 6.20.938
ALP (IU/L)44 ± 2549 ± 861 ± 1974 ± 310.140
TBil (mg/dL)0.27 ± 0.080.24 ± 0.070.25 ± 0.110.33 ± 0.210.865
UBil (mg/dL)0.13 ± 0.050.13 ± 0.060.16 ± 0.100.17 ± 0.120.825
CBil (mg/dL)0.15 ± 0.030.09 ± 0.050.10 ± 0.070.16 ± 0.090.318
Table 2 Shear wave elastography elastic modulus (kPa, median ± IQR) by fibrosis grade (n = 14)
VariableF0 controlF2F3F4P value
(n = 2)(n = 3)(n = 7)(n = 2)
LSM5.0 ± 0.416.5 ± 5.41,214.6 ± 9.42,328.3 ± 17.840.004
Table 3 Pharmacokinetics (median ± IQR) of plasma monoethylglycinexylidide (n = 14)
VariableF0 controlF2F3F4P value
(n = 2)(n = 3)(n = 7)(n = 2)
C10 min (ng/mL)252 ± 31197 ± 38199 ± 10572 ± 380.280
C30 min (ng/mL)327 ± 561268 ± 3751,2120 ± 312,373 ± 203,40.033
C60 min (ng/mL)274 ± 711258 ± 3361,293 ± 262,351 ± 373,40.020
Cmax (ng/mL)327 ± 56282 ± 332143 ± 10682 ± 220.069
tmax (min)30.0 ± 0.040.0 ± 20.030.0 ± 20.017.5 ± 5.00.120
t½max (min)141.3 ± 110.1151.1 ± 188.346.9 ± 50.274.9 ± 75.90.545
AUC (ng/mL·min)16644 ± 3139114421 ± 25151,26100 ± 22862,33970 ± 16703,40.016
Kmax (ng/mL/min)43.7 ± 7.238.1 ± 83.817.7 ± 22.86.6 ± 1.50.358