Lymphocyte-to-monocyte ratio predicts survival after radiofrequency ablation for colorectal liver metastases

Table 1 Baseline characteristics of the study population

Variable
Age (yr)	66 (38-88)
Gender (M/F)	88 (69.2%)/39 (30.8%)
Absolute lymphocyte count (103 cells/μL)	1.77 (0.45-5.98)
Absolute neutrophil count (103 cells/μL)	3.29 (0.98-12.17)
Absolute monocyte count (103 cells/μL)	0.35 (0.01-2.15)
NLR (%)	1.74 (0.33-13.09)
LMR (%)	4.38 (0.79-88)
CEA (ng/mL)	34.2 (1.5-1198)
Number of Nodules	2 (1-3)
Max diameter (mm)	27 (10-45)
Primary tumor (colon/rectum)	95 (74.8%)/32 (25.2%)
Timing of occurrence (synchronous/metachronous)	98 (77.1%)/29 (22.9%)
ECOG performance status (0/1)	112 (88.1%)/15 (11.9%)

Values are expressed as median (range) or absolute numbers (percentages) when appropriate. NLR: Neutrophil-to-lymphocyte ratio; LMR: Lymphocyte-to-monocyte ratio; CEA: Carcinoembryonic antigen; ECOG: Eastern Cooperative Oncology Group.

Table 2 Cox univariate/multivariate regression for overall survival

Variables	Univariate analysis		Multivariate analysis
	Hazard ratio (95%CI)	P value	Hazard ratio (95%CI)	P value
Age (reference ≤ 65 yr)	1.16 (0.68-1.95)	0.39
Gender (reference F)	1.41 (0.58-3.1)	0.14
Monocyte ratio (reference ≤ 5%)	1.38 (0.46-2.78)	0.16
NLR (reference ≤ 2.1)	1.62 (0.87-3.64)	0.03	1.48 (0.22- 2.79)	0.14
LMR (reference ≤ 3.96)	0.53 (0.34-0.85)	0.007	0.49 (0.29-0.96)	0.02
CEA (reference ≤ 34 ng/mL)	1.83 (1.24-4.07)	0.01	1.38 (1.03-2.54)	0.32
Number of nodules (reference 1)	1.69 (1.13-4.22)	0.02	1.27 (2.02-6.63)	0.48
Max diameter (reference ≤ 30 mm)	2.1 (1.59-5.1)	0.002	2.49 (1.45-5.46)	0.001
Primary tumor (reference colon)	1.18 (0.46-1.43)	0.34
Timing (reference synchronous)	1.29 (0.77-1.84)	0.21
ECOG PS (reference 0)	1.54 (0.94-2.75)	0.09

NLR: Neutrophil-to-lymphocyte ratio; LMR: Lymphocyte-to-monocyte ratio; CEA: Carcinoembryonic antigen; ECOG: Eastern Cooperative Oncology Group; PS: Performance status.

Table 3 Cox univariate/multivariate regression for time to recurrence

Variables	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Age (reference ≤ 65 yr)	1.01 (0.57-1.59)	0.61
Gender (reference F)	1.29 (0.63-1.91)	0.52
Monocyte ratio (reference ≤ 5%)	1.23 (0.47-2.11)	0.45
NLR (reference ≤ 2.1)	1.49 (0.88-2.89)	0.04	1.28 (0.21- 4.75)	0.26
LMR (reference ≤ 3.96)	0.62 (0.40-0.95)	0.02	0.41 (0.25-0.89)	0.01
CEA (reference ≤ 38 ng/mL)	1.69 (1.04-4.21)	0.02	1.38 (1.12-3.48)	0.22
Number of nodules (reference 1)	1.41 (1.11-3.64)	0.05	1.53 (1.23-3.49)	0.10
Max Diameter (reference ≤ 30 mm)	2.29 (1.58-5.2)	< 0.001	3.59 (1.86-6.31)	0.003
Primary tumor (reference colon)	1.12 (0.52-1.64)	0.48
Timing (reference synchronous)	1.21 (0.89-1.75)	0.41
ECOG PS (reference 0)	1.01 (0.72-1.34)	0.87

NLR: Neutrophil-to-lymphocyte ratio; LMR: Lymphocyte-to-monocyte ratio; CEA: Carcinoembryonic antigen; ECOG: Eastern Cooperative Oncology Group; PS: Performance status.