Retrospective Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 28, 2016; 22(16): 4211-4218
Published online Apr 28, 2016. doi: 10.3748/wjg.v22.i16.4211
Lymphocyte-to-monocyte ratio predicts survival after radiofrequency ablation for colorectal liver metastases
Antonio Facciorusso, Valentina Del Prete, Nicola Crucinio, Gaetano Serviddio, Gianluigi Vendemiale, Nicola Muscatiello
Antonio Facciorusso, Valentina Del Prete, Nicola Crucinio, Nicola Muscatiello, Gastroenterology Unit, Department of Medical Sciences, University of Foggia, 71100 Foggia, Italy
Gaetano Serviddio, Gianluigi Vendemiale, Internal Medicine Unit, University of Foggia, 71100 Foggia, Italy
Author contributions: Facciorusso A designed the study, performed the statistical analysis and wrote the paper; Crucinio N performed the treatment procedures; Del Prete V and Muscatiello N collected the data; Vendemiale G and Serviddio G revised the paper.
Institutional review board statement: This study was approved by the Institutional Review Board of the University of Foggia for retrospective evaluation of de-identified patients.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: None of the authors have received fees for serving as a speaker or are consultant/advisory board member for any organizations. None of the authors have received research funding from any organizations. None of the authors are employees of any organizations. None of the authors own stocks and/or share in any organizations. None of the authors own patents.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Antonio Facciorusso, MD, Gastroenterology Unit, Department of Medical Sciences, University of Foggia, Viale L.Pinto, 1, 71100 Foggia, Italy. antonio.facciorusso@virgilio.it
Telephone: +39-881-732154 Fax: +39-881-732135
Received: December 12, 2015
Peer-review started: December 12, 2015
First decision: December 30, 2015
Revised: December 31, 2015
Accepted: January 30, 2016
Article in press: January 30, 2016
Published online: April 28, 2016
Processing time: 129 Days and 6.3 Hours
Core Tip

Core tip: This is a retrospective study to test the correlation between baseline lymphocyte-to-monocyte ratio (LMR) and survival outcomes in colorectal liver metastasis patients treated with radiofrequency ablation. Median overall survival (OS) was 55 mo in patients with LMR > 3.96% and 34 mo in patients with LMR ≤ 3.96% (P = 0.007). Time to recurrence (TTR) was 35 mo in the group > 3.96% and 25 mo in the group ≤ 3.96% (P = 0.02). Nodule size and LMR were the only significant predictors either for OS and for TTR in multivariate analysis. LMR was useful as clinical predictor of survival outcomes.