Copyright
©The Author(s) 2016.
World J Gastroenterol. Apr 14, 2016; 22(14): 3785-3792
Published online Apr 14, 2016. doi: 10.3748/wjg.v22.i14.3785
Published online Apr 14, 2016. doi: 10.3748/wjg.v22.i14.3785
Type A (n = 34) | Type B (n = 53) | Type C (n = 80) | P value | |
Age (yr)c | 51.9 ± 10.3 | 54.0 ± 10.3 | 58.0 ± 11.1 | 0.010 |
Male | 20 (58.8) | 32 (60.4) | 59 (73.8) | 0.159 |
Predisposition | ||||
HBVc | 21 (61.8) | 19 (35.9) | 28 (35.0) | 0.020 |
Alcoholac | 4 (11.8) | 25 (47.2) | 33 (41.3) | 0.001 |
HCV | 0 (0.0) | 0 (0.0) | 6 (7.5) | 0.051 |
Autoimmunec | 6 (17.7) | 2 (3.8) | 2 (2.5) | 0.008 |
Others | 3 (8.8) | 7 (13.2) | 11 (13.8) | 0.827 |
Injury | ||||
Hepaticace | 30 (88.2) | 31 (58.5) | 9 (11.3) | < 0.001 |
Extrahepaticace | 0 (0.0) | 13 (24.5) | 44 (55.0) | < 0.001 |
Unknowne | 4 (11.8) | 4 (7.6) | 23 (28.8) | 0.005 |
Both (hepatic + extrahepatic) | 0 (0.0) | 5 (9.4) | 4 (5.0) | 0.165 |
Response | ||||
MELD score | 29 ± 8.3 | 27 ± 5.7 | 26 ± 6.3 | 0.137 |
SIRS | 9 (26.5) | 19 (35.9) | 30 (37.5) | 0.516 |
Organ failures by CLIF-SOFA | ||||
Type of organ failure | ||||
Nonee | 8 (23.5) | 8 (15.1) | 28 (35.0) | 0.035 |
Hepatic/coagulationce | 19 (55.9) | 34 (64.2) | 21 (26.3) | 0.000 |
Extrahepaticc | 7 (20.6) | 11 (20.8) | 31 (38.8) | 0.038 |
Specific organ type | ||||
Hepaticce | 26 (76.5) | 42 (79.3) | 28 (35.0) | < 0.001 |
Coagulation | 10 (29.4) | 11 (20.8) | 21 (26.3) | 0.630 |
Renal | 7 (20.6) | 5 (9.4) | 17 (21.3) | 0.182 |
Cerebral | 2 (5.9) | 4 (7.6) | 11 (13.8) | 0.418 |
Circulatoryce | 1 (2.9) | 4 (7.6) | 16 (20.0) | 0.021 |
Respiratory | 2 (5.9) | 1 (1.9) | 4 (5.0) | 0.679 |
Number of organ failure | ||||
Nonee | 8 (23.5) | 8 (15.1) | 28 (35.0) | 0.035 |
Onee | 13 (38.2) | 29 (54.7) | 26 (32.5) | 0.036 |
≥ 2 | 13 (38.2) | 16 (30.2) | 26 (32.5) | 0.733 |
Type A | Type B | Type C | P value | |
HBV flareace | 17 (50.0) | 11 (20.8) | 4 (5.0) | < 0.001 |
Alcoholae | 3 (8.8) | 19 (35.9) | 6 (7.5) | < 0.001 |
HAV | 3 (8.8) | 1 (1.9) | 1 (1.3) | 0.130 |
Toxine | 5 (14.7) | 9 (17.0) | 3 (3.8) | 0.021 |
AIH flarec | 7 (20.6) | 2 (3.8) | 0 (0.0) | < 0.001 |
Infectionac | 0 (0.0) | 13 (24.5) | 32 (40.0) | < 0.001 |
Varix bleeding | 0 (0.0) | 3 (5.7) | 11 (13.8) | 0.035 |
Other bleeding | 0 (0.0) | 2 (3.8) | 6 (7.5) | 0.215 |
Unknowne | 4 (11.8) | 4 (7.6) | 23 (28.8) | 0.005 |
- Citation: Hong YS, Sinn DH, Gwak GY, Cho J, Kang D, Paik YH, Choi MS, Lee JH, Koh KC, Paik SW. Characteristics and outcomes of chronic liver disease patients with acute deteriorated liver function by severity of underlying liver disease. World J Gastroenterol 2016; 22(14): 3785-3792
- URL: https://www.wjgnet.com/1007-9327/full/v22/i14/3785.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i14.3785