Hypothalamic paraventricular nucleus stimulation reduces intestinal injury in rats with ulcerative colitis

Table 1 Colonic damage score scoring criteria

Characteristic	Score
Ulcer
No ulcer	0
Punctate hyperemia, no ulcer	1
Ulcer, no hyperemia or bowel wall thickening	2
Ulcer with inflammation	3
Ulcer with two or more inflammations	4
The length of ulcer damage was greater than l cm along the longitudinal axis of the colon	5
The length of ulcer damage was greater than 2 cm along the longitudinal axis of the colon, each additional 1 cm of the disease, score plus 1	6-10
Adhesions
No adhesions	0
Slight adhesions (the colon can easily be separated with other tissues)	1
Severe adhesions	2
Diarrhea
No diarrhea	0
Have diarrhea	1
	Total score

Table 2 Superoxide dismutase activity and malondialdehyde content in colon tissue of rats with ulcerative colitis

Group	SOD (U/mg)	MDA (nmol/mg)
Normal group	111.23 ± 12.13	3.51 ± 0.45
UC group	46.35 ± 7.21a	6.28 ± 0.94a
Vehicle group	45.98 ± 7.36	6.53 ± 0.83
PVN (12 μg) group	109.38 ± 13.02c	3.13 ± 0.50c

^aP < 0.05, UC group vs the normal group;

^cP < 0.05, PVN (12 μg) group vs the UC group and vehicle group. PVN: Paraventricular nucleus; SOD: Superoxide dismutase; MDA: Malondialdehyde; UC: Ulcerative colitis.