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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 14, 2016; 22(14): 3769-3776
Published online Apr 14, 2016. doi: 10.3748/wjg.v22.i14.3769
Published online Apr 14, 2016. doi: 10.3748/wjg.v22.i14.3769
Hypothalamic paraventricular nucleus stimulation reduces intestinal injury in rats with ulcerative colitis
Quan-Jun Deng, Department of Neurosurgery, General Hospital Affiliated to Tianjin Medical University, Tianjin 300052, China
Ding-Jing Deng, Jin Che, Hai-Rong Zhao, Department of Gastroenterology, General Hospital Affiliated to Tianjin Medical University, Tianjin 300052, China
Jun-Jie Yu, Yong-Yu Lu, Department of Cerebral Surgery, People’s Hospital of Haimen, Haimen 226100, Jiangsu Province, China
Author contributions: Deng QJ and Lu YY designed the research; Deng QJ, Deng DJ, Che J, Zhao HR, Lu YY and Yu JJ performed the research; Deng DJ, Che J, Zhao HR and Lu YY contributed new reagents/analytic tools; Deng QJ, Lu YY and Yu JJ analyzed the data; and Deng QJ and Lu YY wrote the paper.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of Haimen People’s Hospital.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the General Hospital Affiliated to Tianjin Medical University (IACUC protocol number: Shanghai Lab Animal Research Center, CP-GUIDE-IACUC-0458).
Conflict-of-interest statement: We declare that there is no conflict of interest to disclose in this study.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yong-Yu Lu, Associate Chief Physician, Department of Cerebral Surgery, People’s Hospital of Haimen, People’s Road West, No. 253, Haimen 226100, Jiangsu Province, China. luyongyu8@sina.com
Telephone: +86-513-82217820 Fax: +86-513-82217820
Received: November 29, 2015
Peer-review started: November 30, 2015
First decision: December 16, 2015
Revised: January 11, 2016
Accepted: January 17, 2016
Article in press: January 19, 2016
Published online: April 14, 2016
Peer-review started: November 30, 2015
First decision: December 16, 2015
Revised: January 11, 2016
Accepted: January 17, 2016
Article in press: January 19, 2016
Published online: April 14, 2016
Core Tip
Core tip: This study confirms that the chemical stimulation of the paraventricular nucleus with glutamic acid reduces intestinal injury in ulcerative colitis (UC). Furthermore, this study also discusses the possible regulatory mechanism of the central nervous system of rats with UC, so as to provide a theoretical basis for clinical treatment of UC.