Observational Study
Copyright ©The Author(s) 2016.
World J Gastroenterol. Mar 21, 2016; 22(11): 3252-3260
Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3252
Table 1 Characteristics of 4738 participants n (%)
AllDiabetesNon-diabetesP value
(n = 4738)(n = 603)(n = 4135)
Age (yr)60.0 ± 14.365.0 ± 11.959.3 ± 14.5< 0.001
Age ≥ 65 (yr)2102 (44.4)345 (57.2)1757 (42.5)< 0.001
Male sex2988 (63.1)472 (78.3)2516 (60.9)< 0.001
Height 1163.3 ± 9.2165.3 ± 8.7162.9 ± 9.3< 0.001
Weight 261.1 ± 12.365.8 ± 12.760.3 ± 12.0< 0.001
2BMI, kg/m222.8 ± 3.524.0 ± 3.922.6 ± 3.4< 0.001
Lifestyle factors
Current smoker2297 (48.5)337 (55.9)1960 (47.4)< 0.001
Current alcohol consumption2735 (57.7)322 (53.4)2413 (58.4)0.021
Chronic disease
Hypertension1520 (31.9)338 (56.1)1172 (28.3)< 0.001
Dyslipidemia802 (16.9)169 (28.0)633 (15.3)< 0.001
Cerebro- cardiovascular disease435 (9.2)106 (17.6)329 (8.0)< 0.001
Chronic kidney disease160 (3.4)56 (9.3)104 (2.5)< 0.001
Liver cirrhosis318 (6.7)42 (7.0)276 (6.7)0.790
Familial history of colorectal cancer351 (7.4)43 (7.1)308 (7.5)0.781
Medication
NSAIDs407 (8.6)53 (8.8)354 (8.6)0.852
Low-dose aspirin445 (9.4)111 (18.4)334 (8.1)< 0.001
Thienopyridine130 (2.7)40 (6.6)90 (2.2)< 0.001
Dipyridamole40 (0.84)4 (0.7)36 (0.9)0.603
Cilostazol55 (1.2)19 (3.2)36 (0.9)< 0.001
Anticoagulants231 (4.9)40 (6.6)191 (4.6)0.032
Cecum intubation rate3484 (97.1)592 (98.2)4042 (97.8)0.506
Colorectal disease on colonoscopy with pathology
Colorectal cancer80 (1.7)16 (2.7)64 (1.6)0.049
Post-colectomy for colorectal cancer227 (4.8)40 (6.6)187 (4.5)0.023
Other colorectal tumor362 (1.3)8 (1.3)54 (1.3)0.967
Inflammatory bowel disease246 (5.2)19 (3.2)227 (5.5)0.016
Ischemic colitis50 (1.1)3 (0.5)47 (1.1)0.151
Other colitis50 (1.1)3 (0.5)47 (1.1)0.151
Table 2 Associations between diabetes and bowel symptoms (n = 4738)
GI symptomCrude ORP valueAdjusted ORP valueAdjusted ORP value
Model 11Model 22
Borborygmus0.81 (0.68-0.96)0.020.93 (0.78-1.11)0.430.94 (0.78-1.14)0.53
Abdominal distension1.00 (0.84-1.19)0.981.10 (0.91-1.30)0.341.04 (0.86-1.26)0.71
Increased flatus1.14 (0.97-1.33)0.111.12 (0.96-1.32)0.151.15 (0.97-1.37)0.10
Constipation1.47 (1.26-1.73)< 0.0011.57 (1.33-1.85)< 0.0011.43 (1.20-1.70)< 0.001
Diarrhea0.88 (0.75-1.04)0.130.98 (0.83-1.15)0.770.97 (0.81-1.17)0.77
Loose stools0.96 (0.82-1.13)0.661.06 (0.90-1.25)0.501.02 (0.86-1.23)0.79
Hard stools1.57 (1.34-1.84)< 0.0011.56 (1.33-1.84)< 0.0011.50 (1.26-1.78)< 0.001
Fecal urgency1.13 (0.97-1.33)0.121.16 (0.99-1.37)0.071.20 (1.01-1.43)0.04
Incomplete evacuation1.11 (0.96-1.30)0.171.16 (1.00-1.36)0.061.16 (0.98-1.37)0.08
Table 3 Test-retest reliability of bowel symptom score between 1st and 2nd questionnaire
Bowel symptomsAll (n = 1197)
Diabetes (n = 152)
Non-Diabetes (n = 1045)
Kappa valueSEP valueKappa valueSEP valueKappa valueSEP value
Borborygmus0.670.02< 0.0010.690.05< 0.0010.670.02< 0.001
Abdominal distension0.680.02< 0.0010.710.05< 0.0010.680.02< 0.001
Increased flatus0.670.02< 0.0010.670.04< 0.0010.670.02< 0.001
Constipation0.700.02< 0.0010.710.04< 0.0010.700.02< 0.001
Diarrhea0.700.02< 0.0010.730.05< 0.0010.690.02< 0.001
Loose stools0.700.02< 0.0010.770.05< 0.0010.700.02< 0.001
Hard stools0.680.02< 0.0010.750.04< 0.0010.670.02< 0.001
Fecal urgency0.690.02< 0.0010.690.04< 0.0010.690.02< 0.001
Incomplete evacuation0.680.02< 0.0010.730.04< 0.0010.670.02< 0.001
Table 4 Associations between diabetes-related factors and the bowel symptoms in patients with diabetes (n = 241)
Number of patients (%) or mean ± SDCrude ORP valueAdjusted OR (Model 1)1P valueAdjusted OR (Model 2)2P value
Constipation
HbA1c ≥ 8.0% (64 mmol/mol)54/241 (22.4)2.11 (1.22-3.64)< 0.012.10 (1.21-3.66)< 0.012.11 (1.19-3.73)0.01
Duration of diabetes (yr)13.0 ± 8.91.02 (0.99-1.04)0.221.02 (1.00-1.05)0.101.02 (0.99-1.05)0.22
BMI < 25 kg/m²137/230 (59.6)1.62 (0.99-2.64)0.061.76 (1.06-2.93)0.032.11 (1.22-3.66)< 0.01
Cerebro-cardio vascular disease37/241 (15.3)1.51 (0.82-2.80)0.191.38 (0.73-2.62)0.331.13 (0.56-2.27)0.73
Creatinine (μmol/L)109.6 ± 149.40.97 (0.81-1.21)0.710.97 (0.81-1.16)0.741.02 (0.84-1.23)0.87
Urine protein positive51/224 (22.8)0.95 (0.53-1.70)0.850.89 (0.49-1.61)0.700.83 (0.44-1.58)0.57
Hypoglycemic agents
Insulin69/241 (28.6)1.83 (1.11-3.03)0.021.82 (1.07-3.09)0.031.90 (1.08-3.36)0.03
Sulfonylurea75/241 (31.1)0.77 (0.46-1.29)0.320.79 (0.46-1.34)0.380.72 (0.41-1.26)0.25
Glinide21/241 (8.7)1.52 (0.66-3.48)0.321.72 (0.75-3.95)0.202.00 (0.83-4.82)0.12
Alpha-glucosidase inhibitors68/241 (28.2)1.01 (0.60-1.68)0.981.04 (0.62-1.76)0.880.99 (0.58-1.71)0.98
Biguanide104/241 (43.1)1.24 (0.78-1.99)0.361.32 (0.81-2.13)0.261.38 (0.82-2.30)0.22
Thiazolidine28/241 (11.6)0.88 (0.41-1.86)0.730.86 (0.40-1.84)0.690.87 (0.40-1.92)0.74
DPP-4 inhibitors36/241 (14.9)0.73 (0.38-1.39)0.330.77 (0.40-1.49)0.440.83 (0.42-1.62)0.58
Hard stool
HbA1c ≥ 8.0% (64 mmol/mol)54/241 (22.4)1.72 (0.99-2.98)0.051.75 (1.00-3.03)< 0.051.71 (0.97-3.02)0.06
Duration of diabetes (yr)13.0 (± 8.9)1.02 (1.00-1.05)0.081.03 (1.00-1.06)0.071.03 (1.00-1.07)0.04
BMI < 25 kg/m²137/230 (59.6)1.24 (0.76-2.01)0.391.28 (0.78-2.11)0.331.44 (0.85-2.45)0.17
Cerebro-cardio vascular disease37/241 (15.3)1.28 (0.68-2.40)0.441.15 (0.60-2.21)0.671.31 (0.65-2.65)0.45
Creatinine (μmol/L)109.6 ± 149.41.08 (0.94-1.23)0.281.09 (0.95-1.25)0.221.12 (0.97-1.30)0.12
Urine protein positive51/224 (22.8)1.08 (0.60-1.93)0.801.04 (0.57-1.87)0.911.07 (0.57-2.03)0.83
Hypoglycemic agents
Insulin69/241 (28.6)1.08 (0.65-1.81)0.761.10 (0.65-1.88)0.721.08 (0.61-1.90)0.79
Sulfonylurea75/241 (31.1)0.65 (0.39-1.08)0.100.63 (0.37-1.06)0.080.65 (0.38-1.13)0.13
Glinide21/241 (8.7)1.94 (0.83-4.51)0.132.07 (0.88-4.89)0.102.20 (0.90-5.39)0.08
Alpha-glucosidase inhibitors68/241 (28.2)1.16 (0.69-1.93)0.571.19 (0.70-2.01)0.521.08 (0.63-1.86)0.78
Biguanide104/241 (43.1)1.01 (0.63-1.61)0.981.05 (0.65-1.70)0.830.97 (0.59-1.62)0.92
Thiazolidine28/241 (11.6)0.84 (0.39-1.80)0.650.81 (0.38-1.75)0.590.76 (0.35-1.66)0.49
DPP-4 inhibitors36/241 (14.9)0.69 (0.35-1.33)0.270.70 (0.36-1.37)0.290.75 (0.38-1.47)0.40
Fecal urgency
HbA1c ≥ 8.0% (64 mmol/mol)54/241 (22.4)0.99 (0.56-1.74)0.970.94 (0.53-1.67)0.830.96 (0.53-1.72)0.88
Duration of diabetes (yr)13.0 ± 8.91.01 (0.98-1.03)0.651.00 (0.98-1.03)0.761.01 (0.98-1.04)0.56
BMI < 25 kg/m²137/230 (59.6)1.62 (0.98-2.67)0.061.81 (1.08-3.03)0.031.73 (1.00-2.98)< 0.05
Cerebro-cardio vascular disease37/241 (15.3)1.41 (0.73-2.71)0.311.41 (0.72-2.78)0.321.74 (0.84-3.59)0.14
Creatinine (μmol/L)109.6 (± 149.4)1.16 (0.98-1.39)0.091.15 (0.97-1.36)0.121.14 (0.94-1.39)0.18
Urine protein positive51/224 (22.8)0.72 (0.39-1.33)0.290.70 (0.38-1.29)0.250.78 (0.40-1.51)0.45
Hypoglycemic agents
Insulin69/241 (28.6)1.59 (0.95-2.66)0.081.65 (0.96-2.83)0.071.67 (0.94-2.95)0.08
Sulfonylurea75/241 (31.1)0.56 (0.33-0.93)0.030.57 (0.33-0.96)0.030.61 (0.35-1.07)0.08
Glinide21/241 (8.7)1.29 (0.57-2.91)0.551.38 (0.60-3.16)0.451.43 (0.59-3.44)0.42
Alpha-glucosidase inhibitors68/241 (28.2)1.17 (0.70-1.96)0.541.18 (0.70-1.98)0.531.22 (0.71-2.08)0.47
Biguanide104/241 (43.1)1.55 (0.97-2.48)0.071.63 (1.01-2.63)< 0.051.65 (0.99-2.73)0.05
Thiazolidine28/241 (11.6)0.77 (0.52-2.12)0.901.08 (0.53-2.21)0.831.23 (0.60-2.54)0.58
DPP-4 inhibitors36/241 (14.9)0.64 (0.33-1.26)0.200.64 (0.32-1.30)0.200.67 (0.34-1.34)0.26
Incomplete evacuation
HbA1c ≥ 8.0% (64 mmol/mol)54/241 (22.4)1.49 (0.85-2.60)0.161.50 (0.86-2.64)0.151.49 (0.84-2.64)0.18
Duration of diabetes (yr)13.0 ± 8.91.02 (1.00-1.05)0.081.02 (1.00-1.06)0.071.03 (1.00-1.06)0.08
BMI < 25 kg/m²137/230 (59.6)2.09 (1.29-3.40)< 0.012.21 (1.34-3.65)< 0.012.60 (1.52-4.43)< 0.01
Cerebro-cardio vascular disease37/241 (15.3)1.67 (0.89-3.12)0.111.61 (0.84-3.07)0.151.81 (0.90-3.61)0.09
Creatinine (μmol/L)109.6 ± 149.41.24 (1.08-1.42)< 0.011.25 (1.09-1.43)< 0.011.27 (1.10-1.47)< 0.01
Urine protein positive51/224 (22.8)1.41 (0.80-2.48)0.241.38 (0.78-2.45)0.271.45 (0.79-2.69)0.23
Hypoglycemic agents
Insulin69/241 (28.6)1.65 (0.99-2.76)0.051.77 (1.03-3.02)0.041.92 (1.09-3.38)0.02
Sulfonylurea75/241 (31.1)0.85 (0.52-1.40)0.530.83 (0.50-1.38)0.470.89 (0.52-1.52)0.68
Glinide21/241 (8.7)2.27 (1.00-5.18)0.052.39 (1.03-5.52)0.042.33 (0.95-5.73)0.06
Alpha-glucosidase inhibitors68/241 (28.2)0.92 (0.55-1.52)0.740.92 (0.55-1.54)0.760.85 (0.50-1.44)0.55
Biguanide104/241 (43.1)1.19 (0.76-1.89)0.441.22 (0.77-1.94)0.401.15 (0.70-1.87)0.58
Thiazolidine28/241 (11.6)1.07 (0.52-2.25)0.841.07 (0.51-2.24)0.861.14 (0.53-2.42)0.74
DPP-4 inhibitors36/241 (14.9)0.49 (0.26-0.94)0.030.49 (0.25-0.94)0.030.52 (0.27-1.01)0.05