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Copyright ©The Author(s) 2016.
World J Gastroenterol. Jan 7, 2016; 22(1): 427-434
Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.427
Table 1 Standardized incidence ratio (95%CI) of non-skin solid cancer after liver transplantation, n (range)
Ref.LT patients (n)CountryMedian follow-up time (yr)All non-skin solid tumorsHead and neckLungColorectalAnalEsophagealPancreaticKidneyProstateUrological tractKaposi’s sarcomaBreastCervical
Engels et al[7]37958United States1.9 (1.7-2.2)1.8 (1.4-2.3)
Collett et al[9]6771United Kingdom2.2 (2-2.4)10 (5.9-16)1.6 (1.2-2.2)2.3 (1.7-3)3.3 (0.4-12)1.8 (0.8-3.6)00.8 (0.5-1.1)
Ettorre et al[18]1675Italy5.20.9 (0.7-1.2)4.5 (2.7-7.1)1.1 (0.9-1.9)1.2 (0.6-2.2)1.1 (0.3-3.9)0.8 (0.3-1.6)0.7 (0.1-1.9)
Aberg et al[6]540Finland6.314.8 (0.4-82)01.6 (0.2-5.7)2.3 (0.1-13)4.2 (0.5-15)1.2 (0.2-4.5)0.3 (0.1-1.4)
Herrero et al[12]297Spain6.52.34 (1.7-3.2)4.1 (1.7-8.5)2.4 (0.6-4)2.5 (1.3-3.5)2.9 (1.7-4.8)
Baccarani et al[8]417Italy6.82.6 (1.9-3.6)7 (3-13.7)1.6 (0.4-4.1)1.4 (0.2-5.1)23.4 (4.6-55)144 (53-313)0.6 (0-3.4)30.7 (6.3-90)
Jiang et al[14]2034Canada2.5 (2.1-3)2.5 (0.5-7.3)1.4 (0.7-2.6)2.6 (1.4-4.4)3.3 (0.7-9.6)3.1 (0.8-7.9)1 (0.3-2.4)0.6 (0.2-1.4)
Haagsma et al[4]174The Netherlands5.14.4 (2.4-7.3)2.7 (1.2-5.2)12.5 (2.5-36)30 (6.1-87)
Hsiao et al[15]444Taiwan4.20 (0-5.7)1.9 (0.2-6.7)0 (0-2.84)6.2 (0.1-34)10.2 (1.1-36)02.3 (0.3-8.4)
Kaneko et al[16]360Japan7.53.7 (0.5-26)3.5 (1.8-7)16.9 (2.4-18)6.4 (1.6-25)2.2 (0.6-8.9)0.9 (0.1-6.4)
Maggi et al[17]494Italy7.22 (1.4-2.9)3.4 (0.9-8.8)2.1 (0.8-4.6)1.6 (0.3-4.6)1.6 (0.4-4.1)2.9 (1-6.9)128 (51-263)1 (0.2-2.9)5.7 (0.1-32)
Carenco et al[13]465France7.83.7 (2.8-4.9)15.8 (9.4-27)5.1 (2.9-9)2.7 (1.3-5.6)10.5 (3.9-28)0
Table 2 Risk factors for non-skin solid tumors after liver transplantation from multivariate analyses
Ref.Risk factorAssociated cancerSIR, HR, RR, or OR (95%CI)
Viral infectionBaccarani et al[8]HPV exposureCervicalSIR = 30.7 (6.3-90)
Collett et al[9]AnalSIR = 3.3 (0.4-12)
Baccarani et al[8]HHV8 exposureKaposi’s sarcomaSIR = 144 (53-313)
Maggi et al[17]SIR = 128 (51-263)
Demographic dataHerrero et al[22]Recipient’s ageAll non-skin tumorsHR = 1.90 (1.32-2.73)
Watt et al[23]All non-skin solid tumorsHR = 1.33 (1.05-1.66)
Herrero et al[34]Smoking-related tumorsHR = 1.09 (1.03-1.15)
Indication for LTWatt et al[23]Alcohol cirrhosisAll non-skin solid tumorsHR = 2.14 (1.22-3.73)
Primary sclerosis cholangitisAll non-skin solid tumorsHR = 2.62 (1.50-4.56)
LifestyleBenlloch et al[53]Alcohol consumptionAll non-skin tumorsRR = 3 (1.5-5.8)
Herrero et al[22]HR = 2.87 (1.15-7.19)
Herrero et al[22]Tobacco consumptionAll non-skin tumorsHR = 3.07 (1.32-7.16)
Watt et al[23]All non-skin solid tumorsHR = 1.72 (1.06-2.79)
Carenco et al[13]OR = 5.5 (2.5-12)
Herrero et al[34]Smoking-related tumorsHR = 19.17 (4.17-88.10)
Carenco et al[13]OR = 14.7 (1.8-119)
Carenco et al[13]ObesityAll non-skin solid tumorsOR = 2.2 (1.1-4.3)
ImmunosuppressionCarenco et al[49]Mean tacrolimus TC during first year post-LTAll non-skin solid tumorsOR = 2.01 (1.57-2.59)