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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 7, 2016; 22(1): 427-434
Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.427
Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.427
Solid, non-skin, post-liver transplant tumors: Key role of lifestyle and immunosuppression management
Christophe Carenco, Stéphanie Faure, José Ursic-Bedoya, Astrid Herrero, Georges Philippe Pageaux, Liver Transplant Unit, CHRU Montpellier, 34090 Montpellier, France
Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.
Conflict-of-interest statement: No potential conflicts of interest. No financial support.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Georges Philippe Pageaux, Professor, Liver Transplant Unit, CHRU Montpellier, 191 Avenue du Doyen Gaston Giraud, 34090 Montpellier, France. gp-pageaux@chu-montpellier.fr
Telephone: +33-4-67337061 Fax: +33-4-99632247
Received: September 1, 2015
Peer-review started: September 1, 2015
First decision: September 29, 2015
Revised: October 18, 2015
Accepted: November 13, 2015
Article in press: November 13, 2015
Published online: January 7, 2016
Processing time: 121 Days and 12.1 Hours
Peer-review started: September 1, 2015
First decision: September 29, 2015
Revised: October 18, 2015
Accepted: November 13, 2015
Article in press: November 13, 2015
Published online: January 7, 2016
Processing time: 121 Days and 12.1 Hours
Core Tip
Core tip: Liver transplantation results in two to five-fold mean increase in the rate of solid organ cancers. In this paper, we review the results of studies assessing the incidence of non-skin solid tumors in post-liver transplant patients to understand the mechanisms underlying solid cancers in these patients, and discuss how to prevent these cancers. Risk of smoking and viral-related malignancies is high, but recent data also implicate the role of calcineurin inhibitors, whose cumulative and dose-dependent effects on cell metabolism might play a direct role in oncogenesis.