New cancer suppressor gene for colorectal adenocarcinoma: Filamin A

Table 1 Expression of filamin A in colorectal adenocarcinoma tissues and normal colorectal tissues

Group	Cases	Expression of filamin A protein			χ2	P
		-	+	+ +
Cancer group	46	24	12	10	32.679	0.000
Normal group	46	4	5	37

Table 2 Expression of filamin A in colorectal adenocarcinoma tissues and its correlation with clinicopathological parameters

Parameters	Cases	Positive expression of filamin A
		Cases	P
Sex
Male	27	12	0.584
Female	19	10
Age
≥ 60 yr	26	10	0.147
< 60 yr	20	12
Tumor location
Colon	17	4	0.238
Rectum	29	18
Liver metastasis
Yes	9	1	0.022
No	37	22
Lymph node metastasis
Yes	33	10	0.000
No	13	12
Gross shape
Uplift	11	5	0.977
Ulcerated	23	11
Infiltrative	12	6
Depth of invasion
Serosal invasion	30	7	0.000
No serosal invasion	16	15
Histological type
Papillary adenocarcinoma	23	12	0.935
Tubular adenocarcinoma	12	6
Mucinous adenocarcinoma	11	5

Table 3 Multivariate analysis of 46 patients

Parameters	B	Wald	df	Sig.	Exp(B)	95%CI
Expression of filamin A protein	-3.274	15.114	1	0.000	3.856	7.326-19.421
Depth of tumor invasion	2.685	6.163	1	0.013	14.657	1.760-122.093
Lymph node metastasis	2.193	10.836	1	0.001	8.958	2.428-33.052