Reduction of the ages at diagnosis and operation of biliary atresia in Taiwan: A 15-year population-based cohort study

Table 1 Case number, incidence, age at diagnosis, Kasai operation and liver transplant, proportion of Kasai operation within 60 d of age and percentage of liver transplant in three year-ranges n (%)

	1997-2001	2002-2006	2007-2011	P value
Case number	208	200	132
Male	97 (46.6)	101 (50.5)	67 (50.8)	0.421
Incidence (per 10000 person-years)	6.68	8.31	6.73	0.6992
Age at diagnosis (d), mean ± SD	57.9 ± 70.0	55.6 ± 55.4	52.6 ± 36.4	0.0353
Age at Kasai operation (d), mean ± SD	58.2 ± 42.0	50.5 ± 30.8	46.0 ± 23.8	0.0063
Age at Liver transplant (d), mean ± SD	958 ± 859	617 ± 638	353 ± 237	0.0063
Kasai operation	188 (90.4)	174 (87.0)	122 (92.4)	0.702
Kasai operation ≤ 60 d 1	144 (76.6)	154 (88.5)	99 (81.1)	0.285
Liver transplant	68 (32.7)	82 (41.0)	39 (29.6)	0.7824

¹Percentage among those receiving Kasai operation;

²Trend test based on Poisson regression model;

³Trend test based on general linear model;

⁴Cochran-Armitage trend test. BA: Biliary atresia.

Table 2 Percentages of liver transplant related to the age of biliary atresia patients receiving Kasai operation

Kasai operation	Liver transplant			Total
	No (n)	Yes (n)	Transplant (%)
Without operation	0	56	100	56
With operation	351	133	27.5	484
Among those with operation
Operation age ≤ 60 d	259	89	25.6a	348
Operation age > 60 d	92	44	32.3a	136

^aP = 0.133, Operation age ≤ 60 d vs Operation age > 60 d.