Copyright
©The Author(s) 2015.
World J Gastroenterol. Jan 28, 2015; 21(4): 1305-1314
Published online Jan 28, 2015. doi: 10.3748/wjg.v21.i4.1305
Published online Jan 28, 2015. doi: 10.3748/wjg.v21.i4.1305
Table 1 Baseline characteristics of the included studies
Ref. | Country | Year | No. of patients | Study design | UBT (13C/14C) | Infrared assisted | Reference standard | Mean age (mean ± SD) | Females | UBT threshold | Time | |
Allardyce et al[13] | New Zealand | 1997 | 63 | Cross-sectional | 14C | No | Histo or (Biopsy and rapid urea test) | 56.5 | 26 | 41% | 82% DPM | 30 min and 60 min post ingestion |
Bruden et al[16] | Estonia | 2011 | 280 | Cross-sectional | 13C | No | Culture or (Histo and RUT) | 53.5 | 185 | 66% | ≥ 5% | NA |
Calvet et al[27] | Spain | 2009 | 199 | Cross-sectional | 13C | Yes | Any two positive (Histopathology, RUT, UBT, and fecal serology) | 48.2 ± 14.2 | 107 | 53% | 8.5% | 20 min after drinking solution |
Chen et al[29] | Taiwan | 2003 | 586 | Cross-sectional | 13C | Yes | Culture alone or RUT | 45.7 ± 13.3 | 280 | 46.6% | ≥ 2% | 20 min after drinking solution |
Chen et al[25] | Japan | 2000 | 169 | Cross-sectional | 13C | No | Combined (Histo and serology) | 53.9 ± 15.7 | 68 | 40% | 2.5% | 20 min after normal respiration |
Gatta et al[30] | Italy | 2003 | 200 | Cross-sectional | 13C | No | Combined (Histology and rapid urease) and/or culture | 53 ± 13 | 113 | 56% | NA | 30 min post ingestion |
Gomes et al[22] | Brazil | 2002 | 137 | Cross-sectional | 14C | No | Combined (Histo and RUT) | 46.7 ± 16.6 | 67 | 45% | 1000-2000 CPM | 30 min post ingestion |
Gomollon et al[17] | Spain | 2003 | 314 | Cross-sectional | 13C | No | Culture and/or Combined (Histo and RUT) | 54.1 ± 18 | 168 | 53.5% | ≥ 5% | 30 min post ingestion |
Gurbuz et al[23] | Turkey | 2005 | 65 | Cross-sectional | 14C | No | Combind tests (Histo and RUT) | 42.4 ± 15.5 | 46 | 67.7% | > 50 CPM | 10 min after drinking solution |
Hahn et al[31] | United States | 2000 | 100 | Cross-sectional | 13C | No | Combined (Histo, UBT and serology) | 58.8 ± 14 | 9 | 13.4% | > 2.3% | 30 min after administration |
Hilker et al[14] | Germany | 1996 | 174 | Cross-sectional | 13C | No | Histo | 46 | 106 | 60.9% | > 250 | 30 min after administration |
van der Hulst et al[26] | Italy | 1999 | 544 | Cross-sectional | 13C | Yes | Histo and culture | 46.5 | 379 | 62.7% | > 5% | 30 min after administration |
Marshall et al[32] | United States | 1990 | 153 | Cross-sectional | 14C | No | Combined (Culture, RUT and histo) | -- | 77 | 50% | > 6% | 30 min after administration |
Ortiz-Olvera Nayeli et al[18] | Mexico | 2007 | 88 | Cross-sectional | 13C | No | Culture and/or combined (Histo and RUT) | 45 ± 15 | 49 | 55.6% | > 4.22% | 30 min after administration |
Ozdemir et al[28] | Turkey | 2008 | 89 | Cross-sectional | 14C | No | Combined; any 2 positive ( RUT, PCR and histo) | 45 ± 13 | 59 | 66% | > 25 CPMas Heliprobe | 10 min after drinking solution |
Oztürk et al[15] | Turkey | 2003 | 75 | Cross-sectional | 14C | No | Histology | 41 ± 14 | 56 | 74.6% | 100 DPM | NA |
Peng et al[19] | Taiwan | 2009 | 100 | Cross-sectional | 13C | Yes | Culture or combind (Histo and RUT) | 55 | 44 | 55% | 4.8% | 15 min after drinking solution |
Perri et al[20] | Belgium | 1998 | 172 | Cross-sectional | 13C | No | Histo and/or culture | 39.7 ± 14.1 | 81 | 47% | 3.3% | Every 15 min for 1 h after ingestion ofthe urea solution |
Kopański et al[3] | Poland | 2002 | 92 | Cross-sectional | 14C | No | Combined (Culture, serology, UBT and urine test for C-urea) | 45.5 | 36 | 39% | > 5% | 30 min after administration |
Rasool et al[24] | Pakistan | 2007 | 94 | Cross-sectional | 14C | No | Two reference tests. Patient did both separately: (1) Histo; (2) RUT | 40.8 ± 12.8 | 34 | 36% | > 50 CPM | After 10 min |
Riepl et al[33] | Austria | 2000 | 100 | Cross-sectional | 13C | Yes | Combined 3 tests (Histo, UAT and culture) | 51.6 ± 1.4 | 49 | 49% | > 4% | NA |
Surveyor et al[21] | Australia | 1989 | 63 | Cross-sectional | 14C | No | Histo and/or culture | 58.8 ± 14.5 | 30 | 47% | NA | Every 5 min for 30 min |
Valdeperez et al[12] | Spain | 2003 | 85 | Cross-sectional | 13C | No | Histo and RUT | 41.6 | 44 | 50.5% | NA | 30 min after administration |
Table 2 Test values of included studies
Ref. | TP | FP | FN | TN | Total |
Allardyce et al[13] | 24 | 2 | 0 | 37 | 63 |
Bruden et al[16] | 131 | 24 | 9 | 116 | 280 |
Calvet et al[27] | 102 | 9 | 11 | 77 | 199 |
Chen et al[29] | 361 | 8 | 10 | 205 | 584 |
Chen et al[25] | 135 | 1 | 0 | 26 | 162 |
Gatta et al[30] | 113 | 1 | 0 | 86 | 200 |
Gomes et al[22] | 112 | 1 | 3 | 21 | 137 |
Gomollon et al[17] | 249 | 0 | 4 | 61 | 314 |
Gurbuz et al[23] | 26 | 8 | 3 | 28 | 65 |
Hahn et al[31] | 4 | 9 | 0 | 54 | 67 |
Hilker et al[14] | 76 | 4 | 0 | 94 | 174 |
van der Hulst et al[26] part 1 | 255 | 14 | 14 | 231 | 514 |
van der Hulst et al[26] part 2 | 161 | 3 | 12 | 72 | 248 |
Marshall et al[32] | 101 | 0 | 3 | 49 | 153 |
Ortiz-Olvera Nayeli et al[18] | 46 | 2 | 5 | 28 | 81 |
Ozdemir et al[28] | 57 | 0 | 2 | 30 | 89 |
Oztürk et al[15] | 48 | 5 | 0 | 20 | 73 |
Peng et al[19] | 53 | 7 | 0 | 40 | 100 |
Perri et al[20] | 121 | 1 | 5 | 46 | 173 |
Kopański et al[3] | 75 | 2 | 0 | 17 | 94 |
Rasool et al[24] | 61 | 2 | 5 | 26 | 94 |
Riepl et al[33] | 30 | 7 | 7 | 63 | 107 |
Surveyor et al[21] | 30 | 2 | 2 | 25 | 59 |
Valdeperez et al[12] | 61 | 0 | 5 | 19 | 85 |
Table 3 Subgroup analysis
Subgroup | No. of studies | Sensitivity | Specificity |
UBT 13C | 14 | 0.96 (0.95-0.97) | 0.94 (0.92-0.95) |
UBT 14C | 9 | 0.97 (0.95-0.98) | 0.91 (0.87-0.94) |
Infrared assisted UBT | 5 | 0.95 (0.93-0.96) | 0.93 (0.91-0.95) |
Infrared not assisted UBT | 18 | 0.97 (0.96-0.98) | 0.93 (0.91-0.95) |
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Citation: Ferwana M, Abdulmajeed I, Alhajiahmed A, Madani W, Firwana B, Hasan R, Altayar O, Limburg PJ, Murad MH, Knawy B. Accuracy of urea breath test in
Helicobacter pylori infection: Meta-analysis. World J Gastroenterol 2015; 21(4): 1305-1314 - URL: https://www.wjgnet.com/1007-9327/full/v21/i4/1305.htm
- DOI: https://dx.doi.org/10.3748/wjg.v21.i4.1305