Characteristics of hepatocellular carcinoma in cirrhotic and non-cirrhotic non-alcoholic fatty liver disease

Table 1 Comparison between non-alcoholic fatty liver disease cirrhotics and cryptogenic cirrhosis in terms of demographics and hepatocellular carcinoma risk factors

	NAFLD cirrhotics (n = 31)	Cryptogenic cirrhotics (n = 15)	P value
Median age (yr)	65	65	0.680
Median BMI (kg/m2)	31.35	28	0.407
Overweight/obesity	72%	73%	0.919
Diabetes	72%	40%	0.058
Hyperlipidaemia	29%	33%	0.952
Hypertension	48%	13%	0.025
Number of risk factors (n)			0.310
0	2	1
1	6	6
2	10	6
3	9	2
4	4	0
Child-Pugh Score			0.880
A	12	6
B	10	4
C	8	5

NAFLD: Non-alcoholic fatty liver disease; BMI: Body mass index.

Table 2 Comparison between cirrhotics and non-cirrhotics in terms of demographics, non-alcoholic fatty liver disease grade and hepatocellular carcinoma characteristics

	Cirrhotics (n = 46)	Non-cirrhotics (n = 8)	P value
Median age (yr)	65	69	0.227
Median BMI (kg/m2)	30	30	0.939
Median HCC diameter (cm)	3.2	4.7	0.041
Median number of HCCs	1	2	0.147
Number of risk factors (n)			0.969
0	3	0
1	12	3
2	16	2
3	11	2
4	4	1
NAFLD grade (n)			0.188
0	8	0
1	9	2
2	5	4
3	3	0
Level of HCC differentation (n)			0.317
Well	10	4
Moderate	7	1
Poor	0	0
Necrotic	1	0

NAFLD: Non-alcoholic fatty liver disease; HCC: Hepatocellular carcinoma; BMI: Body mass index.

Table 3 Comparison between cirrhotics and non-cirrhotics in terms of hepatocelullar carcinoma risk factors

	Cirrhotics (n = 46)	Non-cirrhotics (n = 8)	P value
Overweight/obesity	74%	75%	0.660
Diabetes	61%	50%	0.410
Hyperlipidaemia	24%	37.50%	0.340
Hypertension	43%	50%	0.767

Table 4 Correlations between patient characteristics and tumour size

	Pearson correlation	P value
Overweight/obesity	-0.256	0.093
Diabetes	0.038	0.791
Hypertension	0.106	0.470
Dyslipidaemia	0.146	0.510
Age at diagnosis	0.142	0.320
Gender	0.042	0.770
BMI	-0.026	0.867
Number of risk factors	-0.090	0.534
Stage of fibrosis	-0.308	0.030
Grade of NAFLD	0.243	0.196
Child-Pugh Score	-0.170	0.238

NAFLD: Non-alcoholic fatty liver disease; BMI: Body mass index.

Table 5 Correlations between patient characteristics and tumour number

	Pearson correlation	P value
Overweight/obesity	0.174	0.248
Diabetes	-0.270	0.053
Hypertension	-0.040	0.779
Dyslipidaemia	0.080	0.715
Age at diagnosis	-0.041	0.771
Gender	-0.090	0.523
BMI	0.064	0.677
Number of risk factors	0.055	0.696
Stage of fibrosis	-0.058	0.682
Grade of NAFLD	-0.192	0.310
Child-Pugh Score	0.179	0.208

NAFLD: Non-alcoholic fatty liver disease; BMI: Body mass index.