Change of strategies and future perspectives against hepatitis B virus recurrence after liver transplantation

Table 1 Comparison of amounts and costs of hepatitis B immunoglobulin for combination prophylaxis with nucleos(t)ide analogues in previous publications[7,51]

Ref.	Patients (n)	Protocol (HBIg)	Follow-up months median or average	HBV recurrence	HBIg amount V/1000IU/3 mo	HBIg cost US dollars
Markowitz et al[45]	14	80KIU iv 1st month	12	0	100	40000
		Then 10KIU iv/mo
Yao et al[[52]	10	80KIU iv + 3.3KIU im x 1 mo	15.6	1 (10)	86.26	34500
		Then 1.48KIU im/mo
Yoshida et al[53]	18	43.4KIU im 1st month	18	0	52-67	20800-26800
		4.3-6.8KIU im/mo thereafter
Mazano et al[47]	33	46.5KIU iv 1st week	30	1 (3)	56.5	23000
		5KIU/mo thereafter
Rosneau et al[46]	21	45KIU iv 1st week	21	2 (9.5)	> 45	> 18000
		HBsAb > 500 until 14POD
		HBsAb > 200 thereafter
Roche et al[31]	15	80KIU iv 1st month	> 120	1 (6.6)	100	40000
		10KIU/month iv thereafter
Han et al[48]	59	80KIU iv 1st month	35	0	100	40000
		10KIU/month iv thereafter
Seehofer et al[54]	17	80KIU iv 1st month	25	3 (18)	83-84	25200-25600
		1.5-2KIU/month to maintain
		HBsAb > 100
Wong et al[55]	21	70KIU iv 1st month	25	2 (9.5)	90	36000
		10KIU/month iv thereafter
Takaki et al[56]	18	200IU/kg iv for 1 wk	18	0	47	18800
		HBsAb > 100 following 5 mo
		HBsAb > 10 thereafter
Buti et al[14]		10KIU iv anhepatic phase	18	1 (7.1)	52	20800
		5KIU iv following 6 d
		4KIU im following 3 wk

For these calculations, 1 US dollar = 100 yen. Estimated cost of HBIg: 400 dollars. HBV: Hepatitis B virus; HBIg: Hepatitis B immunoglobulin.