Should temporary extracorporeal continuous portal diversion replace meso/porta-caval shunts in “small-for-size” syndrome in porcine hepatectomy?

Table 1 Characteristics of the experimental groups and hemodynamic studies

	Control group	Diversion group	P value
Body weight (kg)	17.4 ± 3.3	18.1 ± 3.5	0.97
Left tri-lobes (g)	351.2 ± 14.9	365.5 ± 15.8	0.81
ETL (g)	442.7 ± 18.4	457.0 ± 19.7	0.86
WRL (g)	390.7 ± 19.4	401.8 ± 20.4	0.79
ERL (g)	55.7 ± 3.8	60.8 ± 4.1	0.91
Proportion of ERL (%)	12.8 ± 2.3	13.2 ± 3.5	0.87
OT (min)	115 ± 23	121 ± 28	0.45
Blood loss (mL)	35.7 ± 13.8	45.1 ± 16.1	0.73

Data are expressed as mean ± SD. Estimated total liver weight = (weight of left tri-lobes) × 100/80. ETL: Estimated total liver weight; ERL: Estimated residual liver weight; WRL: Weight of resected liver.

Table 2 Serial changes in portal vein flow, hepatic artery flow and portal vein pressure

	Control group	Diversion group	P value
PVF, mL/min per 100 g
BAS	61.9 ± 9.6	64.1 ± 10.6	0.87
2 h PH	431.8 ± 36.6	238.8 ± 29.3	< 0.01
48 h PH (re-open)	210.3 ± 23.4	122.3 ± 20.6	< 0.01
Pre-EUT1	204.5 ± 21.4	211.4 ± 26.3	0.94
HAF, mL/min per 100 g
BAS	19.4 ± 4.5	19.9 ± 4.1	0.96
2 h PH	6.1 ± 2.5	14.9 ± 2.5	< 0.01
48 h PH (re-open)	5.5 ± 2.1	13.2 ± 4.2	0.011
Pre-EUT1	5.3 ± 2.0	11.2 ± 3.4	0.014
P/A
BAS	3.1 ± 0.2	3.4 ± 0.2	0.89
2 h PH	74.0 ± 8.1	14.8 ± 3.1	0.01
48 h PH	40.8 ± 6.6	9.5 ± 1.8	< 0.01
Pre-EUT1	41.3 ± 6.3	19.1 ± 2.5	< 0.01
PVP, mmHg
BAS	6.4 ± 1.8	6.0 ± 0.8	0.94
2 h PH	13.8 ± 2.6	8.7 ± 1.4	< 0.01
48 h PH	15.6 ± 2.1	10.1 ± 1.3	0.021
Pre-EUT1	15.1 ± 1.9	11.4 ± 1.8	0.032

¹ECPD was stopped for 1 h. This table depicts the changes in hemodynamic parameters measured at baseline, 1 h, and 48 h PH and before euthanasia in the two groups of animals. All flow values are reported in mL/min per 100 g hepatic tissue. NS: Not significant; BAS: Baseline; EUT: Euthanasia; HAF: Hepatic artery flow; P/A: Portal-to-arterial flow ratio; PR: Portal reperfusion; PVF: Portal vein flow; PVP: Portal vein pressure; HAF: Hepatic artery flow.