Copyright
©The Author(s) 2015.
World J Gastroenterol. Jul 28, 2015; 21(28): 8644-8652
Published online Jul 28, 2015. doi: 10.3748/wjg.v21.i28.8644
Published online Jul 28, 2015. doi: 10.3748/wjg.v21.i28.8644
Variable | Case |
Total | 1490 |
Sex | |
Male | 1150 (77.2) |
Female | 340 (22.8) |
Age (yr) | |
≤ 58 | 796 (53.4) |
> 58 | 694 (46.6) |
Tumor location | |
Upper thoracic | 181 (12.1) |
Middle thoracic | 831 (55.8) |
Lower thoracic | 478 (32.1) |
Pathologic T status | |
T1 | 6 (0.4) |
T2 | 373 (25.0) |
T3 | 1039 (69.7) |
T4a | 72 (4.8) |
Pathologic N | |
N0 | 727 (48.8) |
N1 | 419 (28.1) |
N2 | 267 (17.9) |
N3 | 77 (5.2) |
Tumor cell differentiation | |
Well | 349 (23.4) |
Moderate | 727 (48.8) |
Poor | 414 (27.8) |
Surgical approach | |
Left thoracotomy | 917 (61.5) |
Ivor-Lewis/tri-incisional | 573 (38.5) |
Resected lymph nodes number | |
≤ 14 | 764 (51.3) |
≥ 15 | 726 (48.7) |
Received treatment | |
Surgery alone | 1171 (78.6) |
Combined treatment | 319 (21.4) |
Factors | Surgical approach | Resected lymph nodes (n) | ||
Left transthoracic | Ivor-Lewis/tri-incisional | ≤14 | ≥15 | |
In patients with N0 status (n = 727) | ||||
No. at risk | 445 | 282 | 391 | 336 |
No. of events | 204 | 106 | 215 | 95 |
aHR (95%CI) | 1 | 0.632 (0.499-0.801) | 1 | 0.478 (0.375-0.609) |
P value1 | < 0.001 | < 0.001 | ||
In patients with N1 status (n = 419) | ||||
No. at risk | 254 | 165 | 219 | 200 |
No. of events | 183 | 97 | 174 | 106 |
aHR (95%CI) | 1 | 0.661 (0.516-0.847) | 1 | 0.464 (0.364-0.592) |
P value1 | 0.001 | < 0.001 | ||
In patients with N2-3 status (n = 344) | ||||
No. at risk | 218 | 126 | 154 | 190 |
No. of events | 170 | 99 | 127 | 142 |
uHR (95%CI) | 1 | 0.826 (0.644-1.058) | 1 | 0.849 (0.668-1.078) |
P value2 | 0.130 | 0.179 |
Factors | Surgery alone | Combined therapy |
In patients with N0 status (n = 727) | ||
No. at risk | 644 | 83 |
No. of events | 275 | 35 |
uHR (95%CI) | 1 | 0.878 (0.617-1.249) |
P value1 | 0.469 | |
In patients with N1 status (n = 419) | ||
No. at risk | 313 | 106 |
No. of events | 217 | 63 |
aHR (95%CI) | 1 | 0.712 (0.537-0.944) |
P value2 | 0.018 | |
In patients with N2-3 status (n = 344) | ||
No. at risk | 214 | 130 |
No. of events | 169 | 100 |
aHR (95%CI) | 1 | 0.672 (0.521-0.867) |
P value3 | 0.002 |
- Citation: Zheng YZ, Zhao W, Hu Y, Ding-Lin XX, Wen J, Yang H, Liu QW, Luo KJ, Huang QY, Chen JY, Fu JH. Aggressive surgical resection does not improve survival in operable esophageal squamous cell carcinoma with N2-3 status. World J Gastroenterol 2015; 21(28): 8644-8652
- URL: https://www.wjgnet.com/1007-9327/full/v21/i28/8644.htm
- DOI: https://dx.doi.org/10.3748/wjg.v21.i28.8644