PillCam COLON 2© in Crohn’s disease: A new concept of pan-enteric mucosal healing assessment

Table 1 Inclusion and exclusion criteria

Inclusion and exclusion criteria
Inclusion criteria (all of the following)
Small bowel plus colonic Crohn's disease
Non-stricturing, non-penetrating phenotype
Corticosteroid-free remission (Harvey-Bradshaw Index < 5)
Follow-up ≥ 1 yr
Age ≥ 18 yr
Exclusion criteria (any of the following)
Pregnancy
Intestinal obstruction/obstructive symptoms
Intestinal surgery
Non-steroidal anti-inflammatory drug use within 4 wk of enrolment

Table 2 Hematological results at diagnosis and follow-up (mean ± SD)

Result	Diagnosis	Follow-up	Reference
Hemoglobin (g/dL)	13.2 ± 2.8	14.2 ± 1.4	12.0-18.0
Leucocytes (103/μL)	10.100 ± 3.200	7.800 ± 2.800	4.8-10.8
Platelets (103/μL)	363 ± 194	265 ± 124	150-350
Erythrocyte sedimentation rate (mm/h)	28.6 ± 23.8	12.3 ± 8.3	0-14
C-reactive protein (mg/L)	42.6 ± 36.4	17.2 ± 17.0	< 2.9
Ferritin (ng/mL)	120 ± 112	74 ± 49	26-388
Albumin (ng/mL)	4.1 ± 0.6	3.9 ± 0.3	3.1-17.5

Table 3 Patient characteristics, Crohn's disease therapy and endoscopic findings

Patient	Age (yr)	Sex	Follow-up (mo)	Therapy	SBCE LS	Index colonoscopy colon findings	PCC2 LS	PCC2 colon findings
1	21	Male	48	Azathioprine 2.5 mg/kg per day	2980	Extensive ulcers and erythema in entire colon	1068	Extensive ulcers in entire colon
2	21	Female	63	Azathioprine 2.5 mg/kg per day Adalimumab 40 mg eow	1440	Extensive ulcers and erythema in entire colon	2336	No lesions
3	26	Male	57	Azathioprine 2.5 mg/kg per day Adalimumab 40 mg eow	1350	Aphtoid ulcers and erythema in the sigmoid	562	No lesions
4	48	Male	33	Azathioprine 2.5 mg/kg per day	1240	Aphtoid ulcers and erythema in the cecum	5392	Extensive ulcers in the ascending and transverse colon
5	24	Male	39	Mesalazine 3 g/d	1104	Aphtoid ulcers in the cecum	1518	Aphtoid ulcers in the cecum
6	27	Female	14	Azathioprine 2.5 mg/kg per day	900	Extensive ulcers and erythema proximal to the splenic flexure	0	Ulcers in the transverse colon
7	18	Male	14	Azathioprine 2.5 mg/kg per day	1690	Extensive ulcers and erythema in entire colon	2336	Ulcers in the cecum, ascending, transverse and descending colon
8	35	Female	22	Azathioprine 2.5 mg/kg per day	314	Aphtoid ulcers and erythema in the cecum	5392	No lesions
9	32	Male	22	Mesalazine 3 g/d	458	Extensive ulcers and erythema in entire colon	0	No lesions
10	46	Female	49	Azathioprine 2.5 mg/kg per day	393	Extensive ulcers and erythema proximal to the splenic flexure	0	No lesions
11	50	Female	65	Azathioprine 2.5 mg/kg per day	225	Ulcers in the sigmoid	8	Ulcerative lesions in the splenic flexure;
12	39	Male	62	Mesalazine 3 g/d	168	Aphtoid ulcers in the cecum and ascending colon	0	No lesions

SBCE: Small bowel capsule endoscopy; LS: Lewis Score; eow: Every other week; PCC2: PillCam COLON 2^©.